1. Duke: meaning suffering; pleasure, pain, and desire lead to attachment which leads to suffering and anguish
2. Samudaya: meaning origin of suffering; the origin is the obsessive attachment to what we want, and obsessive aversion to what we don't want
3. Nirodha: meaning cessation of suffering; the cure is to practice ridding oneself of such obsession
4. Marga: meaning the path - Eightfold Path; best accomplished through right views, intentions, right speech, action, etc.