research presentation help

Intro

Hello, I’m Bishop Curry, a sophomore neuroscience student at XULA, and this is our project of synthesizing and studying triazole based small molecules as FXIIa inhibitors.

Whats your role?

As of now I’m on literature review, but soon ill be participating in testing.

What is the goal of the project?

the long-term goal is to introduce better anticoagulants that can treat and prevent thrombotic disorders without causing internal bleeding.

hypothesis

The development of potent and selective inhibitors that target human FXIIa specifically, can lead to discovery of effective and safer anticoagulants.

What’s wrong with Anticoagulants now? 

• All anticoagulants have the dangerous side effect of bleeding  

• Current anticoagulants are dangerous to people with liver and kidney problems 

What's FXII? 

• A trypsin like serine protease  

• An enzyme that initiates the intrinsic pathway of the coagulation cascade. Resulting in the blood clotting. 

Why are you trying to inhibit FXII? 

• Because it was discovered that people with a natural deficiency in FXIIa didn’t experience any abnormal bleeding. 

• it effects thrombosis but not hemostasis

• FXII-deficient mice were found to be protected against arterial thrombosis, collagen-& epinephrine-induced thromboembolism, and ischemic stroke without suffering from spontaneous or prolonged injury-related bleedings2.

Why hasn’t this been researched further? 

• Because modern anticoagulants are cheap to produce and easy to prescribe.