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Biological Bases of Matter, States of Consciousness, Sensation
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Genetic Predisposition
Increased chance of developing a specific trait or condition due to our genetic code.
Determines sex
23rd Pair of Chromosomes
Turner’s Syndrome (Abnormality)
Single X chromosome in the 23rd pair
Turner’s Syndrome
Short stature, webbed necks, differences in physical sexual development.
Klinefelter’s Syndrome (Abnormality)
Extra X chromosome, XXY pattern
Klinefelter’s Syndrome
Minimal sexual development and personality traits like extreme introversion.
Down Syndrome (Abnormality)
Extra chromosome on the 21st pair
Down Syndrome
Rounded face, shorter fingers and toes, slanted eyes set far apart and some degree of intellectual disability.
Neuroanatomy
Study of the parts and functions of neurons
Neurons
Individual nerve cells
Dendrites
Root-like parts of the cell which stretch out from the cell body, grow to make synaptic connections with other neurons
Cell Body/Soma
Contains the nucleus and other parts of the cell needed to sustain its life
Axon
Wirelike structure ending in the terminal buttons that extend from the cell body.
Myelin Sheath
A fatty covering around the axon of some neurons that speeds neural impulses.
Multiple sclerosis
Myelin sheath deteriorates around neurons, interfering with neural transmission. Symptoms of muscle weakness, coordination problems and fatigue
Terminal Buttons
The branched end of the axon that contain neurotransmitters.
Neurotransmitters
Chemicals in terminal buttons to allow neurons to communicate. Neurotransmitters fit into receptor sites on the dendrites of neurons like a key fits into a lock.
Synapse
The space between the terminal buttons of one neuron and the dendrites of the next neuron.
Neurotransmission
All the parts of a neuron work in a sequence to transmit a message.
Resting State/Potential
Neuron has an overall slightly negative charge (-70mV) because mostly negative ions are within the cell and positive ions are surrounding it. Cell membrane is selectively permeable to maintain this difference in charge.
Threshold
Once enough neurotransmitters are received, cell membrane becomes permeable. All the positive ions rush into the cell bringing the charge to around +40mV. The change in charge spreads down the entire length.
Action Potential
The change in charge spreads down the length of the neuron at a speed of 120m/s.
All-or-none Principle
A neuron cannot fire a little or a lot, if dendrites receive enough to push the neuron past the threshold it will fire, and if not it won’t.
Depolarization (also known as neural firing)
Cell fires due to the resting potential of the cell, the negative charge becoming depolarised when positive ions rush in, changing the charge from overall negative to positive.
Excitatory Neurotransmitters
Excite the next cell into firing
Inhibitory Neurotransmitters
Inhibit the next cell from firing
Dopamine
Motor movement, alertness, attention, emotions, movement learning
Parkinson’s
Lack of dopamine
Schizophrenia
Excess dopamine
Serotonin
Mood control, hunger, sleep, arousal
Clinical Depression
Lack of serotonin
Norepinephrine
Alertness, arousal, increases blood pressure/heart rate, helps with fight-or-flight response
Depression
Lack of norepinephrine
Glutamate
Excitatory, memory, long-term memory, learning
Glutamate (problems)
Migraine, seizures
GABA
Important inhibitory, sleep, movement, slows down nervous system
GABA (Problems)
Internalises during seizures, sleep problems
Endorphins
Pain control, pain tolerance
Endorphins (Problem)
Involved in addictions
Substance P
Pain perception, transmitting pain signals from sensory neurons to CNS
Lack of pain perception
Lack of Substance P
Acetylcholine
Motor movement, muscle action, learning, memory
Acetylcholine (Problem)
Myasthenia gravis (muscle weakness)
Alzheimer’s
Lack of Acetylcholine
Sensory/Afferent Neurons
Body to brain
Interneurons/Association Neurons
Take the messages and send elsewhere
Motor/Efferent Neurons
Brain to body
Central Nervous System
Consists of brain and spinal chord, nerves encased in bone, the body’s decision maker
Peripheral Nervous System
all nerves not encased in bone, transmits decisions of CNS
Somatic Nervous System
Controls voluntary muscle movements
Autonomic Nervous System
Controls involuntary functions (heart, lungs, internal organs etc.), stress responses such as the fight-or-flight response, operates autonomously
Sympathetic Nervous System
Mobilizes/arouses our body to respond to stress, accelerates heart rate, blood pressure, breathing but slows digestion to conserve energy
Parasympathetic Nervous System
Calms our body’s response to stress, return to homeostasis, counteracts parasympathetic nervous system
Glial Cells (Glia)
Cells in the nervous system that support, nourish and protect neurons; may also play a role in learning, thinking and memory. Structure, insulation, communication, waste transportation.
Refractory Period
a brief resting pause that occurs after a neuron has fired; subsequent action potentials cannot occur until the axon returns to its resting state
Reuptake
a neurotransmitter’s reabsorption by the sending neuron
Endocrine System
System of glands that secrete hormones, controlled by hypothalamus
Hormones
Chemical messengers manufactured by the endocrine glands, travel through bloodstream and affect other tissues
Adrenaline
Activated during fight or flight in stressful situations, speeds up bodily processes
Adrenal Glands
Produce adrenaline/epinephrine
Leptin
Involved in weight regulation, suppresses hunger (food less appetizing)
Ghrelin
Motivates eating/increases hunger (food more appetizing), growth hormone
Melatonin
Triggers sleep and wakefulness responses in brain, pineal gland, circadian rhythms
Oxytocin
Promotes good feelings such as trust and bonding, produced in hypothalamus and released in pituitary gland
Phineas Gage Accident
Experienced damage to the front part of the brain and doctors documented changes in behaviour and personality after the accident. Changes in emotional control, became highly emotional and impulsive.
Lesioning
Removal or destruction of part of the brain
Frontal Lobotomy
Historically used to control mentally ill patients who had no other treatment options
Electroencephalogram (EEG)
Detects brain waves, used in sleep research to identify the different stages of sleep and dreaming
Computerized Axial Tomography (CAT/CT)
Uses several x-ray cameras which rotate around the brain to create a 3D image, only shows structure not function (eg. good to identify tumour)
Magnetic Resonance Imaging (MRI)
Similar to CAT (gives a picture), more detailed images because of different technology, only shows structure not function
Positron Emission Tomography (PET)
See what areas of the brain are most active, how much of a certain chemical (eg. glucose) parts of the brain are using, more glucose = higher activity, higher activity = warm reds and oranges, lower activity = cool blues and greens
Functional MRI (fMRI)
Combines MRI and PET, can show details of brain structure with info about blood flowing brain, tying brain structure to activity
Hindbrain
Life support system, controls the basic biological functions which keep us alive
Medulla
Control of blood pressure, heart rate and breathing
Pons
Control of facial expressions
Cerebellum
Coordinates habitual muscle movements
Midbrain
Coordinates simple movements with sensory information
Reticular Formation
Netlike collection of cells that controls body arousal and attention, if fails body goes into a deep coma
Forebrain
Responsible for thoughts and reason
Thalamus
Receives sensory signals coming up spinal cord and sending them to appropriate areas of the forebrain
Hypothalamus
Controls metabolic functions: body temperature, sexual arousal/libido, hunger, thirst, endocrine system, biological rhythms (being a morning/night person)
Amygdala
Experiences of emotion
Hippocampus
Memory system
Cerebral Cortex
As we grow up the neurons connect making our brain faster
Left Hemisphere
Gets sensory messages, controls motor functions of right side of the body, more verbal
Right Hemisphere
Gets sensory messages, controls motor functions of left side of the body, visual perception and making inferences, modulate speech, orchestrate self-awareness
Association Area
Any area not associated with sensory info/muscle movements, active thoughts, responsible for judgement and humour
Prefrontal Cortex
Directs thought processes, “central exec,” important in predicting consequences, pursuing goals, emotional control and engaging in abstract thought
Broca’s Area
Controlling muscles involved in producing speech, damage can result in aphasia
Wernicke’s Area
Linguistic processing via written and spoken speech, damage would affect ability to understand, still seem fluent but issues with grammar and syntax
Motor Cortex
Signals to muscles, control voluntary movement, top controls toes bottom controls head
Somatosensory Cortex
Receives incoming touch sensations, top controls toes bottom controls head
Phantom Limb Syndrome
If an individual loses a part they may still perceive sensations due to the mapping of sensory cortex
Occipital Lobes
Interpret messages from our eyes in visual cortex
Visual Cortex
Impulses are sent from retina for interpretation, impulses for right half of retina are processed in the visual cortex of right occipital lobe and same for left
Temporal Lobes
Process sound sensed by ears, processed by ears then turned into neural impulses then interpreted auditory cortices
Brain Plasticity
Brain’s flexibility, compensation level for damage (especially while young)
Conscious
Information that you are currently aware of (about yourself and environment)
Non-conscious
Body processes controlled by the mind that we aren’t aware of (heartbeat, respiration)
Pre-conscious
Information you aren’t currently thinking about (memories)