Blood cells histology

Blood is made up of…

…% cells

…% plasma

45% cells

55% plasma

Which is more numerous - erythrocytes or platelets

erythrocytes

Which is larger - erythrocytes or platelets

erythrocytes

Staining of erythrocytes

Stain pink with eosin due to being acidophilic

What do erythrocytes develop from + where

Reticulocytes in bone marrow

Adaptation of erythrocytes and platelets that make them good at their job

Nucleus lost in development, increasing carrying capacity

What do platelets develop from + where

megakaryocytes in blood marrow

Function of erythrocytes

Transport of oxygen and carbon dioxide between respiratory epithelia and tissues

Function of platelets

Important in clotting and repair of damaged blood vessels

What removes platelets

liver

what destroys erythrocytes

spleen and liver

What are leucocytes and examples

white blood cells - granulocytes and granulocytes

Types of granulocytes

neutrophiles

eosinophils

basophils

function of neutrophiles

first line of defence

appearance of neutrophils

multi lobed nucleus

type of cell

neutrophil

function of eosinophils

destroy parasites in tissue

size of red blood cells vs white blood cells

red blood cells are smaller

type of cell

eosinophil

type of cell

basophil

function of basophil

involved in immune response (phagocytosis and release of histamine)

Types of agranulocytes

lymphocytes

monocytes

what type of cell is this?

monocyte

what type of cell is this?

monocyte

function of lymphocytes

involved in cellular and humoral immunity

function of monocytes

Develop into tissue macrophages and dendritic cells when out of the blood, important in inflammation

How do cells look different in sickle cell disease

Cells become deformed

Purple dots found in cells (fragments of nucleus which should have been removed)

How do cells look different in iron deficiency anaemia

Reduced oxygen carrying capacity – cells become pale in centre

Cells become abnormal shape

What is the reticular fibres

mesh layer which cells sit on

Function of bone marrow

Form erythrocytes, leucocytes, platelets,

Destroy erythrocytes

Store iron

Why do macrophages appear black

Macrophages ingest foreign material via phagocytosis. The animal was injected with India Ink (black) before the tissue was sacrificed the macrophages would have ingested the ink and therefore appear black.

Function of neutrophils

first line of cellular defence