PERFUSION HMG-CoA reductase inhitor

atorvastatin

lipitor

pravastatin

pravachol

rosuvastatin

crestorr

simvastatin

zocor

actions

inhibit HMG-CoA

decrease serum cholesterol levels, LDLS, and triglycerides

increase HDL levels

indications

adjunct to diet in the treatment of elevated cholesterol, triglycerides, and LDL

increase HDL in patients with primary hypercholesterolemia

treat familial hypercholesterolemia and two+ risk factors for CAD

pharmacokinetics

absorbed from GI tract, undergo first pass metabolism by liver

excreted in urine and feces

contraindications

allergy

active liver disease or hx of alcoholic liver disease

pregnancy or lactation

caution

impaired endocrine function

adverse effects

GI: flatulence, ab pain, cramps, nausea, vomiting, and constipation

CNS: headache, dizziness, blurred vision, insomnia, fatigue

liver failure

rhabdomyolysis

drug-drug interaction

erthromycin, cyclosporine, gemfibrozil, niacina

digoxin or warfarin

estrogen

grapefruit juice