Intro-Pasteur (Early vaccination)

Lady Mary Wortley Montagu

Observed the positive effects of variolation on native turkish population

Variolation

Dried crusts are inhaled or inserted into cuts to prevent diseases

Thucydides

Described the plague in athens, those who recovered from plague could nurse the sick as they would not contract the disease twice.

Variola major

Smallpox is caused by a virus called

Edward Jenner

Inoculated an 8 yr old boy with fluid from cowpox postules

Louis pasteur

Next major advance in immunology: immunity to fowl cholera

Vaccine

Weakened or attenuated strains could be administered to provide immunity against disease.

Louis Pasteur

Vaccinated group of sheeps with Bacillus anthracis; heat attenuation

Louis Pasteur

He administered the first vaccine to humans

Joseph Meister

He was inoculated with series of attenuated ravues virus preparation

poxviridae

Cowpox and smallpox belong to the same family _, they share similar structural proteins and antigens.

antigenic similarity

Due to __, memory cells generated for cowpox can recognize also the smallpox.

Louis Pasteur

Father of immunology

• Aging weakens virulence

• Weakened strains provide immunity

Hypothesis of pasteur:

Pasteur Institute

Founded to treat rabies victims; prevention and treatment of infectious diseases.