What Are The Two Main Functions of the Cardiovascular System?
Deliver Oxygen and Nutrients to all cells
Remove Waste
What Pumps and What Delivers?
The heart pumps blood
Blood vessels circulates and delivers blood
How Many Chambers Does the Heart Have?
4
What Are The Two Types of Chambers?
Atria and Ventricles
What do the Atria do?
Receiving chambers
Right and left atria
What do the Ventricles do?
Discharging Chambers
Right and left ventricles
What separates the right and left Atria?
Interatrial Septum
Fossa Ovalis
An opening in the fetal heart that directs blood from the right to the left atrium in order to bypass the nonfunctioning fetal lungs
Remember:
F in Fossa Ovalis is for “fetal”
What separates the ventricles
Interventricular Septum
How does blood flow
Blood only flows in one direction with the help of valves
Atrioventricular Valves
Between Atria and Ventricles
Biscuspid valve (left)
Tricuspid valve (right)
Semilunar valves
Between the ventricle and artery
Pulmonary semilunar valve
Aorti semilunar valve
How are valves held in place
Chordae tendineae hold them in place “heart strings”
Why do valves close?
To prevent backflow
Blood Pressure
a measurement to calculate the pressure in large arteries and how hard the heart works
Systolic Pressure
Pressure at the peak of ventricular contraction
Diastolic
Pressure when ventricles relax
How do pressure and blood pressure relate?
The further away the blood vessel from the heart the lower the blood pressure
Why does the cardiologist like McDonalds
Because it keeps him in business
Intrinsic conduction system
Heart muscle cells contract, without nerve impulses in a regular continuous way
What does the Sinoatrial node do?
It is the pacemaker of the heart
Purkinje fibers
Fibers that release Ca2+ to cause the muscle to contract; intercalated discs continue the contraction
SA Node (Pacemaker)
Has two pathways
Internodal pathway and atrial muscle
Internodal pathway
Av node
Bundle of His
Bundle Branches
Purkinje system
Ventricular myocytes
Action Potential of the Heart
0- Depolarization
Influx of Na+ through FAST Na+ channels
1- Short Repolarization
K+ efflux through K+ channels
2- Plateau Phase
Ca2+ influx through SLOW Ca2+ channels
3- Repolarization
K+ efflux through K+ channels
4 - Resting
What is the Cardiac Cycle
The cycle of mechanical events occurring during one single heart beat
One Heart Beat = how many atrial contractions
1 Heart Beat = 1 cycle = 2 atrial contractions and 2 ventricular contractions
How long does One Cycle Last?
About 0.8 seconds or 72 bpm
How long does the Diastole (relaxation) portion of the cycle take?
About 0.5 seconds
How long does the Systole (contraction) portion take?
About 0.3 seconds
What are the Four Stages of the Cardiac Cycle?
Passive filling (of atrial)
Atrial contraction (ventricles fill with blood)
AV valves close (no backflow)
Semilunar valves open and ventricles contract
The first two steps are Diastole while steps 3,4 are the contraction phase
Cardiac Cycle (in general)
Blood flows from high to low pressures
Contractions of heart chambers increase pressure
AV vales open when the atrial pressure is high
SL valves open when the ventricular pressure is high
If not specified, systole and diastole refer to the ventricles
Isovolumetric means that the volume stays the same
3 phases but 5 steps
How many phases of heart contraction are there?
3
Phase 1: Mid to late diastole/ Atrial depolarization/ contraction
Blood flows into ventricles; AV vales close; 1st heart sound; beginning of ventricular systole
Phase 2: Ventricular systole/ Isovolumertric contraction
SL valves remain closed; vetnricles contract within a closed system; blood pressure builds in ventricles; SL valves open; blood is ejected; ventricular pressure drops ; SL valves close; 2nd heart sound, S2: end of ventricular systole
Phase 3: Early diastole
Ventricles relax; all valves closed; ventricular pressure is low; atrial finish re-filling, atrial pressures rise; ventricular filling starts
What are the Two Heart Sounds?
The Lubb (1st) and Dupp (2nd)
Lubb: Long, booming sound from the AV valves closing
Dupp: Short, sharp shound from the semilunar valves closing at the end of ventricular contraction
Cardiac Output (CO)
Amount of blood pumped by the heart in one minute
Heart rate x stroke volume
Heart rate
Number of times the heart beats in one minute
Stroke Volume
The volume of blood pumped during each cardiac cycle
Stroke volume usually remains constant
Starling’s law of the Heart
The more that the cardiac muscle is stretched, the stronger the contraction and the larger the stroke volume; physiologically important mechanism in making sure that the output of blood by both the right and left ventricles is the same
Changing heart rate
Most common way to change cardiac output
Chemoreceptors
These signal the glossopharyngeal nerve; this nerve goes back to the medulla oblongata
Carotid Sinus
This is where Chemoreceptors for CO2 and pH are
What does the Cardiac Nerve do?
Affects heart rate when working out as well as ventricular contractions
Electrocardiogram (EKG)
Traces the flow of electrical currents through the heart
Picked up by electrodes placed on the skin
P phase of EKG
Atrial contractions
QRS phase of EKG
Results from depolarization of ventricles & signals ventricular contraction
Repolarization of atria also occurs
T phase of EKG
Repolarization of the ventricles