T-cell migration
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What happens to T cells that are not activated by an MHC-peptide complex on an APC?
They exit the secondary lymphoid tissue and re-enter the lymphatic system through an efferent lymphatic vessel.
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How do T cells move back into circulation?
Their movement is mediated by the lipid molecule sphingosine-1-phosphate.
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What additional role does sphingosine-1-phosphate play in T-cell function?
It also influences T-cell movement if the cell becomes activated later.
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