Elsaid M phase agents

What occurs during the M phase

mitosis

How does microtubule grow and collapse

(+) end that is GTP bound is the side that elongates, (-) end is the side that collapses, composed of alpha and beta dimers

What drugs inhibit elongation of microtubules

eribulin and vinblastine

What drugs inhibit collapse of microtubules

paclitaxel and ixabepilone

What happens if microtubule function is hindered

M phase is paused and apoptosis is triggered

M phase agents bind to _ of the microbulin

beta

What are m phase agent classes

vinca alkaloids, taxanes, ixabepilone, eribulin

List vinca alkaloids

vinblastine and vincristine

Name taxanes

paclitaxel docetaxel

Name taxane like drugs

ixabepilone, cabazitaxel

Paclitaxel formulations

oil emulsion (higher allergen risk) and nanoparticle albumin capsule that has higher tolerance

How does NAB-paclitaxel improve outcomes

dec hypersensitivity from castor oil,

enhanced uptake via albumin receptors on cancer cells,

EPR = less side effects

Eribulin MOA

inhibits tubulin polymerization and microtubule elongation

How can cancer cells be resistant to M phase agents

upregulation of B tubulin, mutation in B tubulin, enhanced efflux

Which taxanes are not a substrate of efflux pumps

cabazitaxel