gen microbio antibacterial drugs

penicillin

• effective against Gram + bactera

• natural form can be broken down by beta-lactamase

penicillin derivatives that are acid stable

methicillin, oxacillin

penicillin derivatives that are beta-lactamase resistant

methicillin, oxacillin

penicillin derivatives that are beta-lactamase sensitive

ampicillin and carbenicillin

polymyxin targets ____

cell membrane

polymyxin is used for

pink eye

daptomycin targets..

cell membrane

daptomycin is used for …

Gram+ bacterial infections

how does daptomycin work?

forms pores in cytoplasmic membrane

aminoglycosides target…

protein synthesis

aminoglycoside drugs

neomycin, tobramycin

tetracylcines target…

protein synthesis

macrolides target…

protein synthesis

quinolones target…

nucleic acid synthesis

how do quinolones work?

block dna gyrase

RNA polymerase inhibitor drugs and function

rifampin (tuberculosis)

how do growth factor analogs work?

mimic nutrients to inhibit metabolic reactions

growth factor analogs example and function

isoniazid (effective against mycobacterium by interfering with mycolic acid synthesis)

how do nucleoside analogs work?

block reverse transcriptase

what do antifungals interfere with?

ergosterol, chitin synthesis, folate synthesis, microtubule aggregation

tetracylcine category, target, function

tetracycline, protein synthesis, acne

doxycycline category, target, function

tetracycline, protein synthesis, surgery

erythromycin category, target, function

macrolide, protein synthesis, respiratory/skin infection

azithromycin category, target, function

macrolide, protein synthesis, respiratory/STIs

isoniazid category, function

growth factor analog, blocks mycolic acid synthesis in mycobacterium

patensimycin function

inhibits fatty acid synthesis