COMBINATION DRUG THERAPY FOR TYPE 2 DIABETES

The goal of combination therapy is to:

Improve glycemic control

What is the prototype SGLT2 inhibitor used in triple therapy combos?

Dapagliflozin

BIDS regimen includes:

Bedtime NPH insulin + daytime sulfonylurea

Which drug class increases insulin sensitivity?

Thiazolidinediones

Sulfonylureas increase:

Insulin secretion

Metformin primarily acts by:

Reducing hepatic glucose production

Pramlintide helps control:

Postprandial glucose

A combination of insulin + glitazone:

Increases insulin sensitivity

Metformin + meglitinide requires careful:

Dose titration

Exenatide is:

Incretin mimetic

DPP-4 inhibitors prolong:

Incretin activity

In which combo does pramlintide play a role?

Mealtime insulin + pramlintide

What combo may help delay insulin initiation?

Metformin + sitagliptin

Qtern contains:

Dapagliflozin + saxagliptin

Triple combo Qternmet XR includes:

Dapagliflozin + saxagliptin + metformin

Sulfonylurea + acarbose is approved for:

Patients not controlled on monotherapy

Metformin + thiazolidinedione uses:

Pioglitazone

Monitoring during combo therapy includes:

FPG + A1C

One benefit of combos is:

Lower doses of each agent

Sitagliptin may be added to:

Metformin or thiazolidinedione

A major advantage of exenatide:

Weight loss

Sulfonylurea + metformin is approved with:

Glimepiride

In a triple combo with dapagliflozin, saxagliptin, metformin — if dapagliflozin is new, dose starts at:

Dapagliflozin 5 mg

A reason to stop oral agents and begin insulin:

Inadequate glycemic control

Adding pramlintide helps improve:

Postprandial glucose

BIDS uses NPH insulin at:

Bedtime

Sulfonylurea + thiazolidinedione works by:

↑ insulin + ↑ sensitivity

A combo that helps both fasting & postprandial glucose:

Metformin + exenatide

When using combo therapy:

Monitor both FPG and A1C

One disadvantage of combo therapy can be:

Increased pill burden