Cell Adhesions

Tight Junction

Prevent passages of molecules, fence and gate

Tight Junction components

claudin and occludin molecules

Tight junction diseases

Cholera, toxin in bacteria loosens junctions results in diarrhea

Claudin mutations causes human diseases

Adherens junctions

Bind to actin via alpha and beta catenins

Adheren Junction components

E-cadherins,

Desmosome Junctions

Bind to intermediate filaments via plakoglobin and desmoglobin

Gap junctions

Intracellular channels for ions, second messengers, nucleotides, and amino acids.

Metabolic and electrical synapses

Desmosome diseases

ETA toxin from staph bacteria break it down

PF IgG, antibodies that cause pemphigus vulgaris, blistering skin disease

A mutation in desmoglein 1, keratinocytes lose adhesion

Gap junction components

Hexamer(six subunits) of connexin forms a connexon (the intracellular channel)

Gap Junction Diseases(connexin gene mutations)

Cx-26 deafness

Cx-32 nerve degeneration

Cx-40 cardiac conduction effects

Cx-50 cataract lens