1.2 and 1.3 (PSIO 202)

Heart Conduction, ECGs, Pacemaker and Cardiac APs

What is the structure of cardiac muscle?

branched, striated fibers and usually one centrally located nuclei

What does the branching pattern of cardiac muscle do?

forms a network that can facilitate the multi-directional transmission of electrical impulses in all directions

What connects cardiac muscles together?

intercalated disks

What are gap junctions and why are they important?

small channels that allow electrical impulses to pass quickly from one cell to the next

Where are gap junctions located?

in intercalated discs (lie between adjacent muscle fibers)

What are desmosomes and where are they located?

they hold adjacent cells together; located in intercalated discs

What do gap junctions do for the myocardium?

allow it to behave as a single unit (or functional system)

What is another name for the SA node?

pacemaker

What is the SA node and what does it do?

a mass of cells in the right atrial wall that spontaneously discharge action potentials at a rate of (greater than or equal to) 100-120 bpm

What do autonomic nerves do to the rate of discharge of APs from the SA node?

modify the rate so that HR is \~70 bpm at resting

What ion regulates sustained contraction?

Ca2+

What ion causes depolarization?

Na+

When do Na+ channels close?

at the peak; when the cell depolarizes

What causes the plateau of an action potential?

Ca2+ entering the cell

What is the last ion to enter the cell during an action potential?

K+

What does K+ do to an action potential?

causes a slight fall in the plateau and ultimately returns membrane to resting potential

What is the first step (of 3) of an AP?

rapid depolarization due to inflow of Na+ when Na+ channels open

What is the second step (of 3) of an AP?

plateau (or maintained depolarization) due to inflow of Ca2+ when slow Ca2+ channels open and some K+ channels open causing slight dip in plateau

What is the third step (of 3) of an AP?

repolarization due to Ca2+ channels closing and more K+ channels open causing K+ to leave the cell

What is the absolute refractory period?

the time when a cell will not respond regardless of the strength of stimulus

What is the relative refractory period?

the time when a cell will respond only if the stimulus is “supra-threshold”

When is the absolute refractory period in skeletal and heart muscle?

roughly the same time as the action potential (\~250 ms in heart muscle)

What type of cells are autorhythmic?

pacemaker cells

What does autorhythmic mean?

the cells can auto-initiate action potentials

What is a pacemaker potential?

unstable resting membrane potential

What do pacemaker cells use for the rising phase of the AP instead of sodium?

calcium

What is an ECG?

a composite record of action potentials of all active cells at points in time during a heartbeat

What happens during the P wave?

atrial depolarization

What happens during the P to Q interval?

signal conduction from SA node to AV node; atrial systole begins

What happens during the QRS complex?

atrial repolarization and diastole; repolarization concealed by QRS wave

What happens during the T wave?

ventricular repolarization

What happens during the PR interval?

signal conduction through the AV node, before activating ventricles

What happens during the QT interval?

duration of ventricular depolarization; shorter during exercise

What happens during the ST segment?

ventricular systole and ejection of blood; corresponds to plateau of cardiomyocyte action potential

What is the reading of this ECG?

normal sinus rhythm

What is the reading of this ECG?

atrial fibrillation (multiple P waves)

What is the reading of this ECG?

ventricular fibrillation (heart attack)