neuroinflammation

what is neuroinflammation caused by

• leukocytes invading cns tissue

• significant loss of blood brain barrier integrity

what is neurogenerative processes inflammation triggered by

cns resident cells

• cytokine production

events leading to neuronal damage

1. inc production of cytokines and reactive oxygen species

2. molecular rearrangement of postsynaptic glutamate receptors

3. impairment of hippocampal LTP

4. axonal and dendritic loss

blood brain barrier

• sealed contact of continuous endothelial membrane

• endothelial membrane covered by perictyes

• then covered by astroglial foot

what form of transport across blood brain barrier

active

blood brain barrier breakdown effects

• inc vascular permeability

• toxic blood derived molecules enter brain

• inflammatory and immune responses

• neuronal injury

• synaptic dysfunction

• loss of neurons

• loss of brain connectivity

• neurodegeneration

blood brain barrier disruption in alzheimers

• brain capillary leakages

• pericyte degeneration

• endothelial degeneration

• cellular infiltration

• worst disruption of all diseases

what is the most common bbb disruption

• brain capillary leakages

implications for drug delivery from bbb disruption

• reduced expression of tight junctions, transporters, inflammation and neuron response

• impaired solute transport

• diminished isf regional flow

• dec function of active transport system

• drug, anitbodies and proteins can get trapped in enlarged perivascular spaces