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Catabolic pathways
The breakdown of molecules into smaller units, such as in the pathways of glycolysis and the citric acid cycle.
Amatoxins
Toxins found in mushrooms like Amanita phalloides that selectively inhibit RNA Polymerase II, an essential enzyme in mRNA synthesis.
Chemical Reactions
Involve the breaking and forming of chemical bonds, altering the bonds while maintaining the identity and integrity of atoms.
Free Radicals (Reactive Oxygen Species)
Highly reactive and unstable atoms or molecules with unpaired electrons that can cause damage to cells and tissues.
Antioxidants
Substances that provide electrons and reduce oxidative damage to cells and molecules, such as selenium.
Gibbs Free Energy
The energy available to do work in a system, determining whether a reaction is spontaneous (exergonic) or non-spontaneous (endergonic).
Energetic Coupling
A process where spontaneous reactions drive non-spontaneous reactions.
Intermediate ΔG
Determines whether ATP will be produced or consumed, allowing ATP to drive reactions and be replenished.
Activation Energy
The energy input required for a reaction to reach the transition state, which is unstable and has higher energy compared to other states.
Enzyme-Catalyzed Reactions
Chemical reactions in the body that are sped up by enzymes, which possess an active site where substrates bind and are converted to products.
Active Site Formation
The specific amino acids in the enzyme that compose the active site, which are brought close together through protein folding.
Enzyme Specificity
The ability of enzymes to recognize and bind to specific substrates based on the structure of the active site.
Activators
Substances that increase enzyme activity.
Inhibitors
Substances that decrease or inhibit enzyme activity, which can be reversible or irreversible depending on their binding strength.
Regulation of Chemical Reactions
Allosteric enzymes play a crucial role in regulating chemical reactions.