16. Describe the signal cascade for adrenaline activation of a G-protein coupled receptor in skeletal muscle that leads to glycogen breakdown

Describe the signal cascade for adrenaline activation of a G-protein coupled receptor in skeletal muscle that leads to glycogen breakdown. Part 1

Adrenaline binds to it's G-protein coupled receptor, activating the α subunit of the G-protein (3pts).

Describe the signal cascade for adrenaline activation of a G-protein coupled receptor in skeletal muscle that leads to glycogen breakdown. Part 2

The α subunit activates the enzyme adenylyl cyclase which converts ATP into cAMP (3pts).

Describe the signal cascade for adrenaline activation of a G-protein coupled receptor in skeletal muscle that leads to glycogen breakdown. Part 3

cAMP activates cAMP-dependent protein kinase (PKA) which phosphorylates the inactive phosphorylase kinase (2pts).

Describe the signal cascade for adrenaline activation of a G-protein coupled receptor in skeletal muscle that leads to glycogen breakdown. Part 4

Activated phosphorylase kinase activates glycogen phosphorylase which leads to glycogen breakdown (3pts).