* Ionotropic receptor (has an intrinsic channel gated by ACh), at NMJ there are 5 subunits (2a, 1b, 1d, 1g/e), at CNS there are 5 subunits (3a, 2b). It takes two ACh to gate the channel. Non-selective, allows Na+ or K+ to cross, but Na+ has higher ionic driving force.
* Also can bind to nicotine as an agonist (same effect on the receptor). Has the same stimulant properties when used as a drug.
* a-bungarotoxin and curare are antagonists (inhibit normal function)