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The glomerular filtration rate (GFR) is controlled by various mechanisms, including:
Renal autoregulation: the ability of the kidneys to maintain a constant blood flow and GFR despite changes in blood pressure.
Hormonal regulation: hormones such as angiotensin II, aldosterone, and atrial natriuretic peptide can affect GFR by altering renal blood flow and/or the permeability of the glomerular membrane.
Neural regulation: the sympathetic nervous system can affect GFR by constricting or dilating the afferent arterioles that supply blood to the glomerulus.
Tubuloglomerular feedback: the juxtaglomerular apparatus in the kidney can sense changes in the flow of fluid through the tubules and adjust the resistance of the afferent arterioles accordingly.
Physical factors: the size and charge of the molecules passing through the glomerular membrane can affect GFR, as can the surface area and permeability of the membrane itself.
Kidneys filter blood and remove excess acids or bases.
Urine pH varies from 4.5-8.0 depending on body's need.
Acidic urine excretes H+ ions and basic urine excretes HCO3- ions.