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Epigenetics
environment and behaviors cna cause heritable changes in gene activity without altering DNA sequence
What do epigenetics do?
Turns a gene “on” or “off”
2 main branches of nervous system
Peripheral and Central
2 branches of PNS
Somatic and Autonomic
Somatic NS
communicates sensory neurons to CNS
Autonomic NS
Involuntary functions
Branches of Autonomic NS
Sympathetic and parasympathetic
Sympathetic
Fight or flight: HR, stress hormones, respiration
Parasympathetic
Rest or digest: calms body
Sensory Neurons
Different for each sense, afferent (arrive at brain)
Motor Neurons
Connected to muscles, efferent (exit the brain)
Resting potential
-70 millivolts
Polarized
Positive outside the cell
Firing Threshold
All or none law, same intensity every time
Action potential
30 millivolts
Refractory Period
Brief period when neuron can’t fire
Reuptake
Neurotransmitters reabsorbed by neuron where it originally came from
Most abundant excitatory neurotransmitter
Glutamate
Most abundant inhibitory neurotransmitter
GABA
What does Glutamate do
strengthens synaptic connections
Acetylcholine (ACh)
All movement, learning, memory
Dopamine
Pleasure and reward
Endorphins
Painkiller, creates euphoric feelings
Epinephrine/adrenaline
Fight or flight, works with hormone to boost energy
Norepinephrine
Arousal, alertness, sleep cycle
Serotonin
Mood, appetite, sleep, dreams
Agonist
Enhances actions of neurotransmitters
Direct agonist
mimics neurotransmitter
Indirect agonist
Reputable inhibitors, neurotransmitter stays in synapse
Prozac
Inhibits reputable of serotonin
Cocaine
Inhibits reputable of dopamine
Antagonist
Inhibits action of neurotransmitters, bind but do not stimulate, blocks it form being released or binding to receptor site
Botox
Antagonist for ACh, blocks ACh from reaching receptors
Thorazine
Antagonist for dopamine
All psychoactive drugs
After mental states
Blood brain barrier
Prevents/allows chemicals from blood to brain
4 categories of psychoactive drugs
Depressants, opioids, stimulants, hallucinogens/psychedelics
Heroin
Agonist for endorphins
Depressants
slows/inhibits CNS: drowsiness, sedation, sleep
Alcohol
Depressant, agonist for GABA
Opiates/Opiods
Agonist for endorphins: heroin, fentanyl
Stimulants
Activate sympathetic NS, increase brain activity, HR
Caffeine
Most widely used drug, release dopamine, antagonist for adenosine
Cocaine
Stimulant, agonist for dopamine
Hallucinogens
Create sensory and perceptual distortions