Lipopeptides

Example

daptomycin (Cubicin)

Spectrum

Gram positive

Rarely used reserved for resistant infections or allergic

MRSA

MOA

Rapid depolarisation of cytoplasmic membrane leads to the formation of pores and ion channels

Cause efflux potassium cause ion conc gradient

Preventing nutrient up take

Inhibits ATP synthase can’t make DNA, RNA, Protein Synthesis

Resistance

Rare related to alterations in cellular membrane no cross resistance

Uses

SSTI, endocarditis