Flashcards: Receptors and Ligands

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11 Terms

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• Biological effect
Increases when drug receptor complex increases.
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• Ligand definition
Drug or any substance that activates or inactivates a receptor.
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• Major classes of receptors (1)
Ligand-gated and voltage-gated ion channels (ionotropic).
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• Major classes of receptors (2)
G-protein-coupled receptors (metabotropic).
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• Major classes of receptors (3)
Enzyme linked (Tyrosine kinase-linked) receptors.
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• Major classes of receptors (4)
Intracellular receptors (e.g., steroid receptor).
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• Full agonist
Produces maximum response efficacy.
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• Partial agonist
Produces reduced response or efficacy.
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• Inverse agonist
Produces response below baseline.
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• Agonist properties
Has affinity and efficacy to receptor.
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• Antagonist properties
Has affinity and not have efficacy to receptor.