Flashcards: Receptors and Ligands

• Biological effect

Increases when drug receptor complex increases.

• Ligand definition

Drug or any substance that activates or inactivates a receptor.

• Major classes of receptors (1)

Ligand-gated and voltage-gated ion channels (ionotropic).

• Major classes of receptors (2)

G-protein-coupled receptors (metabotropic).

• Major classes of receptors (3)

Enzyme linked (Tyrosine kinase-linked) receptors.

• Major classes of receptors (4)

Intracellular receptors (e.g., steroid receptor).

• Full agonist

Produces maximum response efficacy.

• Partial agonist

Produces reduced response or efficacy.

• Inverse agonist

Produces response below baseline.

• Agonist properties

Has affinity and efficacy to receptor.

• Antagonist properties

Has affinity and not have efficacy to receptor.