elevated BMI tx

Body Mass Index is a calculated value utilizing which body measurements, what does it directly reflect?

weight divided by height

directly reflects body adiposity

Why is reduction of elevated body mass clinically important?

• medical rationale- elevated body/adipose mas is a disease

• morbidity

• mortality

What are the patient population limitations in use of the BMI?

it doesn’t account for factors like muscle mass, fat distribution, or body composition

• older adults

• children

• athletes

What are the main features of behavioral approaches to weight loss

comprehensive lifestyle intervention, is the initial tx

What is the first-line pharmacotherapy in weight loss

integrin-based Glucagon-Like Peptide 1 (GLP-1) / Glucose-dependent Insulinotropic Polypeptide (GIP) dual receptor agonist (tirzepatide) or the GLP-1 receptor agonists semaglutide and liraglutide

what is mechanism of action for GLP-1

stimulate glucose-dependent insulin secretion; GLP-1 also inhibits glucagon release and gastric emptying thereby inc satiety during meals

What are the goals of pharmacological therapy of obesity

• reduce weight and maintain weight loss

• improve health status

• minimize adverse effects

What are the two distinct strategies of bariatric surgery

• restrictive

• malabsorptive

What is the major obstacle of any of the therapeutic approaches in reducing BMI?

Besides the adverse effects, the  body has a set point or regulated range or regulated range of adipose tissue mass and strategies that assume the effective tx of elevated BMI is only a matter of an individual’s willpower often lead to repeated failure due to the bodys biological/genetic tendency to revert to its set point of adipose mass

what are the common elements of successful weight loss strategies?

-          Make a commitment

-          Food, beverage, and physical activity record

-          Set realistic goals

-          Support resources

-          Continuous monitoring