MMSC423 - EXAM 3 (?) ready to import

Which of the following is necessary to maintain reduced glutathione (GSH) in the mature red blood cell?

G6PD

The RBC membrane is permeable to which of the following?

all of the answers are correct

Which of the following is true regarding carboxyhemoglobin?

smokers have increased levels

Which of the following represents a normal hemoglobin level for an adult male?

15 g/dL

Which of the following describes the sequence of hematopoiesis from the embryo to the adult regarding anatomic sites?

yolk sac, liver, spleen, bone marrow

Which of the following best describes anemia?

decreased hemoglobin, decreased hematocrit, decreased red cell count

What does asplenia refer to?

patient has no functional spleen

The most common site in adults for bone marrow aspiration and biopsy is the:

iliac crest

The nucleus is ejected from which stage of red cell maturation series?

orthochromic erythroblast

In the production of lymphocytes or lymphopoiesis, all of the following are classified as secondary lymphoid tissue, except:

thymus

This abnormal red blood cell is seen in patients with the Rh null phenotype (arrow)

stomatocyte

Which of the following is true of hemoglobin if the hemoglobin-oxygen dissociation curve shifts to the left?

picks up more oxygen in lungs but delivers less to tissues

A bone marrow examination (aspiration/biopsy) would be performed in which of the following?

all answers are correct

An increased concentration of 2,3-DPG:

is present in patients with severe anemia and decreased blood pH (acidosis)

When hematopoiesis occurs in the liver in an adult it is called:

extramedullary

An estimate of bone marrow cellularity is 100 minus the patient age +/- 10%. What specimen is used to determine cellularity?

bone marrow biopsy

What does hemoglobin A2 consist of?

2 alpha and 2 delta chains

Germinal cells in the lymph nodes contain primarily:

B cells

Which of the following stains is used to ascertain iron content of the bone marrow?

prussian blue

What is the lifespan of a normal red blood cell?

120 days

The thymus is responsible for the development of:

T cells

Which of the following describes the Bohr effect?

hydrogen ion attaches to oxyhemoglobin triggering release of oxygen to the tissues

Select the form of hemoglobin that contains iron in the Ferric state, rather than ferrous state?

methemoglobin

What constitutes the normal RBC membrane?

52% protein, 40% lipids, 8% carbs

Which of the following is correct regarding color of blood in methemoglobinemia and sulfhemoglobinemia?

methemoglobin can give a brown color to blood, and sulfhemoglobin a green color

Which of the following is associated with maturation of the red cell series going from rubriblast to mature erythrocyte?

the cell diameter decreases in size

The red cell membrane is impermeable to:

sodium

Which of the following red cell precursors would contain nucleoli?

pronormoblast

How many molecules of oxygen can one molecule of hemoglobin carry?

four

Which of the following causes a shift to the right of the hemoglobin-oxygen dissociation curve?

severe anemia

Which of the following support formation of the ABH blood group antigens on RBC membrane?

glycolipids

What color of red blood cells on a Wright-stained peripheral blood smear would reflect hypochromia?

white

What is meant by "coopertivity" in the hemoglobin oxygen dissociation curve?

ferrous iron and oxygen working together to oxygenate tissues

Which of the following represents the correct sequence of maturation for erythropoiesis?

rubriblast, prorubricyte, rubricyte, metarubricyte, reticulcocyte, erythrocyte

Which of the following represents the correct percentages of normal adult hemoglobin?

>95% hemoglobin A, 1-2% hemoglobin F, <3.5% hemoglobin A2

Which of the following is a normal M:E ratio (myeloid to erythroid ratio)?

3:1

A variation in red cell size is termed:

anisocytosis

Describe the morphologic appearance of red cells given the following lab data: RBC 1.89 x 1012/L, Hgb 7.5 g/dL, Hct 21%, RDW 18.5%, MCV 105 fL

macrocytic with anisocytosis

Heinz bodies contain which of the following?

denatured hemoglobin

What peripheral protein of the red cell membrane is primarily responsible for red cell deformability?

spectrin

Howell-Jolly bodies are made of:

DNA

Which of the following describes the P50?

partial pressure of oxygen at which hemoglobin is fifty percent saturated with oxygen

Synthesis of heme in the mitochondria begins with which of the following?

succinyl coenzyme A and glycine

Which hemoglobins are active during the intrauterine stage?

Gower 1, Gower 2, F, Portland

This hormone is produced in the kidney and binds to receptors on the CFU-E to stimulate maturation of the erythron

erythropoietin

Which pathway is responsible for the production of 2,3-BPG?

Luebering-Rapoport

Which of the following correctly describes the structure of Hgb A?

two alpha and two beta polypeptide chains with each containing one heme group

Why are erythrocyte cellular inclusions such as Howell-Jolly bodies found in the peripheral blood after surgical removal of the spleen?

absent spleen cannot "pit" or remove the inclusion

Myeloperoxidase (MPO) stain preferentially stains which cells?

myeloid

How many cells are counted on a bone marrow aspirate differential?

300-1000

What does VCS refer to in reference to the Coulter Principle?

volume, conductivity, scatter

Which of the following correlates with the RDW (red cell distribution width)?

anisocytosis

Which of the following represents the 3-part differential?

granulocytes, monocytes, lymphocytes

Where does hematopoiesis begin in the embryo?

yolk sac

What does CD refer to?

Cellular demarcation

Cluster differentiation

Cluster demarcation

Cellular designation

cluster differentiation

Which type of leukocyte comprises the majority of leukocytes in the peripheral blood?

segmented neutrophils

Where are megakaryocytes found?

bone marrow

Heme contains what form of iron?

Fe2+

Hemoglobin A consists of:

2 alpha and 2 beta chains

Which of the following is associated with a shift to the right of the hgb-oxygen dissociation curve?

increased 2,3 BPG

What type of abnormal red cell is seen in fragmentation hemolysis?

schistocyte

March hemoglobinuria refers to

condition in which persons develop hemoglobinuria after marching or running on hard surfaces

Which of the following is an integral membrane protein?

band3

Which of the following abnormal red cell shapes is caused by abnormal lipid distribution in red cell membrane?

target cells

Which of the following parameters assesses hypochromia?

MCHC

Which of the following red cells have a teardrop shape?

dacrocyte

the principle of electrical impedance analyzers involves measuring changes in:

electrical resistance

a lipemic sample most commonly interferes with which of the following parameters?

hemoglobin

In a 3-part differential analyzer, the WBCs are typically classified into:

granulocytes, lymphocytes, monocytes

A patient’s CBC reports: RBC = 4.5 x 10¹²/L, Hgb = 13.5 g/dL, Hct = 40%. What is the MCV?

89 fL

what is the corrected reticulocyte count in a patient with Hct=30% and retic count=6%?

3%

a high MCHC (>36 g/dL) is most commonly associated with:

hereditary spherocytosis

which of the following cells is characteristically seen in Rh null syndrome?

stomatocytes

basophilic stippling is associated with which of the following?

lead poisoning

which hemoglobin is predominant in the normal adult?

Hgb A

which condition causes a left shift in the oxygen dissociation curve?

alkalosis

which enzyme protects RBCs from oxidative damage by maintaining gluthionine?

G6PD

which of the following results from fragmentation hemolysis?

schistocytes

the normal M:E ratio in adult bone marrow is approximately:

3:1

which site is most appropriate for bone marrow aspiration in adults?

posterior superior iliac spine

erythropoietin is primarily produced in the:

kidney

which stain is used to visualize iron stores in bone marrow smears?

prussian blue stain

during embryonic development, the first site of hematopoiesis is:

yolk sac

Heinz bodies are composed of

denatured Hgb

which pathway generates 2,3 BPG in RBCs?

Rapoport-Luebering pathway

which hemoglobin variant is elevated in thalassemia minor?

Hgb A2

target cells are also known as:

codocytes

Howell-Jolly bodies represent:

nuclear remnants