generic pKa and pKb values

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Last updated 7:18 PM on 10/6/25
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21 Terms

1
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RCO2H

pKa = 4

2
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ArCO2H

pKa = 4

3
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CF3CO2H

pKa around 1

4
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RSO3H

pKa around 1

5
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ArSO3H

pKa around 1

6
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ROH

pKa = 14

7
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PhOH

pKa = 10

8
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RSH

pKa around 11

9
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H2O

14

10
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NH3

pKb = 5

11
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RNH2

pKb = 5

12
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R2NH

pKb = 5

13
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R3N

pKb = 5

14
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imidazole

pKb = 7

15
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pyridine

pKb around 9

16
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aniline

pKb around 10

17
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DBU (amidine base)

pKb around 2

18
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Guanidine

pKb around 1

19
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pyrrole

pKb = 14

20
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pyrrolidine

pKb around 3

21
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purine

pKb = 4, 5, around 12 (3 basic centers)

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