16.2.12 G-protein coupled receptors (GPCRs)

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4 Terms

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GPCRs

  • integral membrane proteins

  • extracellular region binds hormone

    • intracellular region interacts with G-proteins

2
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Gas

  • activates adenylate cyclase (AC)

  • converts ATP to cAMP

    • cAMP activates protein kinase A (phosphorylates many things)

    • degraded by PDE

3
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Gai

  • inhibits adenylate cyclase (AC)

    • BLOCKS production of cAMP

4
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Gaq

  • activates phospholipase C (PLC)

  • breaks down PIP2, into IP3, and DAG

    • DAG activates protein kinase C

    • IP3 causes calcium release from endoplasmic reticulum

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