Targeted Memory Reactivation

Memory Reactivation

The process in which the firing rates of hippocampal neurons during behavior are correlated with firing rates of the same neurons during subsequent sleep.

5-20

Replays of events during sleep occur ______-_____ times faster than the actual events.

what

TMR does not increase the total number of replays, it only influences ______ is replayed.

weaker

In TMR, cued memories are improved at the cost of ______ non-cued memories.

hippocampus

TMR may effectively trick the ________ by evoking what looks like a spontaneous reactivation of a memory in cortex and influencing what the hippocampus replays.

Temporally spaced re-activations

The repetition of the pattern of hippocampal-cortical reactivations, creating a series of reactivations spaced over time.

Memory triage

A sleep-dependent process in which memories with perceived future relevance are prioritized for consolidation.

decrease

Repeated replay events can gradually decrease the strength of the “tag” associated with a cortical network, leading to a _______ in that network's excitability.

replayed, recent

The trade-off between the number of times a memory has been ______ and its salience relative to other ______ memories, forming a critical feedback mechanism for the memory triage process.