Cancer exam topic 3 and 4
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41 Terms
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What is the difference between G-actin and F-actin?
G-actin is GLOBULAR, F-actin is FILAMENT
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List a few actin-binding proteins:
\-ARP2/3 complex
\-tropomodulin
\-myosin V
\-Catenin and Vinculin
\-tropomodulin
\-myosin V
\-Catenin and Vinculin
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What is treadmilling?
When there is actin de-polarization and polymerization occuring at the same time.
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Why is targetting actin not possible for cancer drugs?
Too Toxic to the cells, not specific to actin in cancers
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What is a tubulin dimer composed of?
1 alpha tubulin + 1 beta tubulin
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Beta-tubulin is a …?
GTPase
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List a few microtubule associated proteins:
Kinesin
Dynein
Dynein
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Towards which end does Kinesin walk towards?
\+
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Towards which end does Dynein walk towards?
\-
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What do Dyneins need to walk?
ATP
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What are Taxanes?
Microtubule-stabilizing agents
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What is an example of a microtubule-destabilizing agent?
Vinca Alkaloids
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True or False “Intermediate filaments need ATP or GTP”
False
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Name a few intermediate filament associated proteins:
Plectin and nesprin
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What is the size of septin diameter?
5nm
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What are septins?
GTPase proteins
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what is septin 9 used for?
Testing for colorectal cancer in blood test
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What is septin 4 used for?
Testing for urothelial cancer using urine test
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name two proteins associated with septin
BORG and cdc42
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Actin pairs with…?
Septin
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Microtubules pairs with ...?
Intermediate filaments
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CDK1 is also known as…?
Cyclin B
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CDK2 is also known as …?
Cyclin A and cyclin E
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CDK4-6 is also known as …?
Cyclin D
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Does WEE1 inhibit or activate CDK1?
Inhibit
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What is WEE1?
A kinase
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Fill in the blank. The cell cycle is regulated by the ……
Proteasome
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What are APC/C Cdh1 AND APC/Cdc20
Ubiquitin Ligases
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HPV protein E6 degrades
p53
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HPV protein E7 binds to
Rb
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At which check point is CDK1 (cyclin B present?)
G2/M checkpoint
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Are G0 cells Ki67 positive or negative?
Negative
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What is Senescence?
A permanent cell cycle arrest
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Which filaments are polarized?
Actin and microtubules
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What are CAF?
Cancer associated fibroblasts
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What is the role of CAF?
facilitate the progression of metastatic tumors by depositing and remodeling the ECM
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What is TEP?
Tumour-educated platelets
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What is the role of TEP?
Platelets educated by the tumour to enable the circulation of cancer cells from the blood stream to the site of the tumour
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What are the three hallmarks related to cancer cell death?
1\.Sustaining proliferative signaling
2. Evading growth suppressors
3. Enabiling replicative immortality.
2. Evading growth suppressors
3. Enabiling replicative immortality.
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What is Myc?
Myc is a proto-oncogene
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