22.7a&b Effector Response of T-lymphocytes and B-lymphocytes

Where do the helper and cytotoxic T-lymphocytes leave and migrate?

They leave the secondary lymhoid structure after exposure to the antigen, migrating to the site of infection where they release cytokines (Il-2 and IL-4)

What do cytotoxic T-lymphocytes destroy?

Unhealthy or infected cells

How does the effector response of a cytotoxic T-lymphocyte initiates?

Physical contact of a cytotoxic T-cell and a specific antigen with MHC I molecule

How does cytotoxic T-cells destroy the infected cells?

Apoptosis

What are the two proteins that cytotoxic T-cells produce and what are their functions?

• Perforin (creates a pore)

• Granzyme (goes in the pore and induces apoptocysis)

What is the purpose of a B-lymphocyte after they matured as plasma cells?

To make antibodies

The circulating blood concentration of antibody against a specific antigen is reffered to as…?

Antibody titer