Type I Diabetes

emotional toll of DM diagnosis

energy homeostasis- insulin

insulin and GLUT4 glucose transporter

normal v. type 1 v. type 2 diabetes

diabetes mellitus

diagnostic criteria for diagnosing diabetes

diabetes mellitus- type 1 and 2

classification and diagnosis of diabetes

diabetes signs and symptoms

history of diabetes

type 1 diabetes current landscape

pathogenesis of type 1 diabetes

genetic predisposition- allelic variants associated with T1D

genetic predisposition

diabetes environment- what triggers destruction?

natural history of type 1 diabetes- Eisenbarth model

natural history of type 1 diabetes- working hypothesis

beta-cell histology progression

relatives of individuals with T1D

classic presentation of type 1 DM

type 1 DM treatment

T1DM- historicl perspective on course of disease

T1DM course of disease

diabetes control and complications trial

hemoglobin A1c

insulin type and action times (type, onset, peak, duration, usage)

basal/bolus insulin concept

basal/bolus insulin concept most closely mimics

-natural insulin release

insulin secretion- non-diabetes state

limitations of current insulin therapy

T1D nutrition

not enough patients achieve

-A1c goals

factors in blood glucose control

psychological burden of T1DM

T1D diagnosis stages

T1D antibodies

when >/=2 autoantibodies are present, lifetime risk of developing clinical stage 3 T1D approaches

-100%

T1D prevention in high-risk patients

recommendations for autoantibody screening to diagnose type 1 diabetes

why screen T1D?

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