03 Answers Study Guide Questions Type III Hypersensitiv 24-06-12 (copy)

Hypersensitivity Reactions

Exaggerated immune responses to antigens that can cause damage to tissues.

Antibody Mediated

Involving antibodies produced by the immune system.

Type III Hypersensitivity Reaction

An immune response where immune complexes form and deposit in tissues, leading to inflammation and tissue damage.

IgG and IgM antibodies

Types of antibodies produced by the immune system in response to antigens.

Immune Complexes

Clusters of antigens bound to antibodies that can trigger immune responses.

Phagocytosis

The process by which cells engulf and digest foreign particles or cells.

Neutrophils

White blood cells that play a role in the immune response, including phagocytosis.

Basophils

White blood cells involved in allergic reactions and inflammation.

Complement Activation

The process by which proteins in the blood enhance the immune response.

Bradykinin

A peptide that causes blood vessels to dilate and increases vascular permeability.

Effector Phase

The stage of the immune response where immune cells act to eliminate antigens.

FcɣR

Receptors on immune cells that bind to the Fc region of antibodies.

Arthus Reaction

A localized immune response that can lead to tissue damage.

Post Streptococcal Glomerulonephritis

Kidney inflammation caused by immune complexes.

Serum Sickness

A systemic reaction to foreign proteins in the blood.

Anti-insulin antibodies

Antibodies that target insulin, detected in a diabetic patient following insulin injections.

Antibody isotype

Refers to the class of an antibody, such as IgA, IgG, IgM, IgE, or IgD, specifying the type of immune response.

Type III HSR

Effector Mechanism:Involves complement activation and immune complex deposition, leading to tissue damage in hypersensitivity reactions.

Snake Bite

A severe injury caused by a snake's venom, which can lead to various immune responses and complications.

Horse anti-venom antibodies

Antibodies injected to neutralize snake venom, leading to potential immune reactions and tissue damage if not cleared properly.

Immune Complex Deposition

Accumulation of immune complexes in tissues, such as the glomerular basement membrane, causing damage in diseases like lupus.

Fc-Fc𝛄R interaction

Interaction between Fc receptors and antibodies, leading to phagocyte activation and tissue damage in immune responses.

Systemic Lupus Erythematosus

An autoimmune disease characterized by immune complex deposition and inflammation, often affecting multiple organs.

Frustrated phagocyte effect

Result of unsuccessful phagocytosis, leading to the release of damaging molecules by activated immune cells.

Arthus reaction

A type III hypersensitivity reaction characterized by local tissue damage due to immune complex deposition, often seen in response to vaccines.

Arthus Reaction

An acute inflammatory response observed in the skin following the injection of an antigen to which the individual has been previously sensitized.

IgG Antibodies

Immunoglobulins produced by the immune system in response to an antigen, playing a key role in the Arthus reaction.

Immune Complexes

Formed when antigens and antibodies bind together, leading to the activation of complement and subsequent inflammatory responses.

Neutrophils

White blood cells that are recruited and activated by C5a to the site of inflammation in the Arthus reaction.