Looks like no one added any tags here yet for you.
EEG/ERP
low spatial resolution
Has very good temporal res
correlational
non invasive (electrodes on scalp)
ECOG
better spatial res than eeg but not as good as fMRI
very good temporal res
correlational
Invasive (electrodes on brain’s surface)
fMRI
excellent spatial res
poor temporal res
correlational
non-invasive (magnetic waves)
TMS
good spatial res
poor temporal res
causal
non-invasive ; on the scalp
VLSM
good spatial res
poor temporal res
correlational
Non-invasive ; image based analysis
structural MRI
excellent spatial res
no temporal resolution
detailed images of brain structure
non-invasive
DTI/DWI
excellent spatial resolution
poor temporal resolution
structural changes and abnormalities in white matter
correlational
non-invasive
PET
moderate spatial res
slow temporal res
analyze neurotransmitter release, receptor binding, and blood flow
correlational
non-invasive
MEG
poor spatial res
excellent temporal res
images neuromagnetic signals
correlational
non-invasive
Patient HM
Severe deficits in acquiring new declarative memories
Working memory intact
retrograde amnesia of ~10 years prior to surgery
Bilateral medial temporal lobe lesions
Bilateral hippocampus and other parts of medial temp. lobe removal to treat epilepsy
couldn’t transfer information from STM to LTM
Patient RB
confirmed role of hippocampus in anterograde amnesia
Ischemic event during surgery
Lesions to CA1 pyramidal cells in hippocampus
anterograde amnesia and retrograde of 1-2 years
Patient KF
left lateral parietal lobe lesion
able to form new declarative memories
severe deficits in holding words in working memory
deficit in phonological loop
Patient KC
Extensive brain damage : Med. Temp. Lobes, dlPFC, Occipital, Parietal
Retrograde amnesia (episodic lost, but retained semantic)
Anterograde amnesia (but could learn semantic at a slower rate)
Clive Wearing
herpes simplex encephalitis
damage to bilateral hippocampus , inferior frontal and temporal lobes
procedural memory intact
few declarative memories beyond the 1960’s
Some semantic memories remain, few episodic memories
emotional memories remain
Sensory and Motor Map representations
Brain-Computer Interface
relies heavily on external computers
Utilized by patients with little/no motor output, deaf or blind individuals
wireless implanted electrodes, alternate to sharp electrodes
Population Vector Coding
the combination of multiple cells preferred directions; if there is a match between the preferred direction, the cell will fire strongly. If the match between the movement and preferred direction is poor, the cell will fire weakly or even be inhibited
Cochlear Implants
captures sound waves from the environment
processed into digital signals
electrodes are inserted into the cochlea, bypassing damaged or non-functioning hair cells
auditory nerve fibers stimulated directly
Functional Roles of Amygdala
emotion processing- primarily fear
important in fear conditioning
forms and stores emotional memories
processes social cues, recognizes facial expressions, and regulates social interactions
initiates physiological response to stress
aids in risk assessment and emotional evaluation of potential outcomes
Functional Roles of Anterior Cingulate Cortex
detects conflicts between competing thoughts, actions, or stimuli and adjusts behavior accordingly
evaluates emotional stimuli, modulates emotional arousal, and regulates emotional expression; dysfunction can lead to mood disorders like anxiety or depression
plays a role in the emotional and cognitive aspects of pain regulation
evaluates the value of rewards, guides decision making related to reward seeking behavior
plays a role in theory of mind, empathy, social decision-making and moral reasoning
involved in error monitoring during movement
Flashbulb memories
a very vivid memory of a powerful event. episodic and very detailed. Is evidence that emotional content is important for memory.
Deep brain Stimulation
major application in Parkinson’s
causal
Better spatial res
Invasive
Parkinsons Disease
Loss of dopaminergic neurons in the substantia nigra
Characterized by hypokinesia and bradykinesia
Hypoactivity of direct pathway
Little movement initiation
Hyperactivity of indirect pathway
Too much movement inhibition
Huntingtons Disease
Genetic neurodegenerative disease caused by a CAG expansion in the huntington (HTT) gene
Striatal neuron (caudate/putamen) loss affects indirect pathway
Decreased inhibition of GPe eventually leads to increased activity of the thalamus
Characterized by hyperkinesia
Movement activation = too much movement
Basal Ganglia Structures
caudate nucleus
putamen
globus pallidus
subthalamic nucleus
substantia nigra
Chomskys view of language
language is standard equipment in humans
Innately guided learning; children will gain language skills unless prevented by extreme circumstances
mental grammar exists
Language network
broca’s area
wernicke’s area
arcuate fasciculus
primary auditory cortex
angular gyrus
supramarginal gyrus
inferior frontal gyrus
posterior superior temporal gyrus
Default mode network
group of brain structures active when the brain is at rest
mPFC
posterior cingulate
precuneus
lateral temporal cortex
inferior parietal lobe
hippocampus
parahippocampal cortex
dmPFC
Brodmann Areas
a system of mapping the cerebral cortex based on cytoarchitectural differences in structure.
Sulcus
a groove in the brain surface
Gyrus
a ridge in the brain surface
Fissure
a deep groove that divides the brain into lobes
Primary sensory cortex location
the parietal lobe, in the postcentral gyrus
Primary motor cortex location
the frontal lobe, in the precentral gyrus
Face processing network
fusiform face area
occipital face area
superior temporal sulcus
anterior temporal lobe
PFC
amygdala
posterior superior temporal sulcus
Double dissociation
2 or 3 groups
Patients with NP1, patients with NP2, and normal controls
2 tasks
People with different kinds of neuropathologies exhibit opposite patterns of deficits
Biological Motion perception
the ability to perceive and interpret movements and actions based on visual cues. The superior temporal sulcus is crucial in processing, along with the mirror neuron system.
Theory of Mind
The cognitive abilities to represent the information in the mind of others, distinguishing them from what we know
Being able to understand that others have thoughts different from one’s own
Block design fMRI
stimuli presented in continuous periods of time, each typically consists of a single condition or task
analyzed by comparing the average during the task to baseline periods
suitable for detecting robust and sustained activations related to specific tasks or conditions
higher statistical power
Event related fMRI
stimuli/events are presented in randomized order
analyzed by modeling the hemodynamic response to each event separately
useful for studying transient or brief
Brain structures involved in episodic memory
hippocampus
Medial Temporal lobe
PFC
amygdala
Brain structures for working memory
PFC (dlPFC, vlPFC, vmPFC)
Posterior parietal cortex
dorsal lateral geniculate nucleus
inferior temporal cortex
basal ganglia
hippocampus
anterior cingulate
Baddeley model
describes working memory as a system with 3 components: central executive, the phonological loop, and the visuospatial sketchpad.
Double dissociation for STM and LTM
refers to the phenomenon in which impairment to one type of memory has little to no effect on the other type
retrograde amnesia
loss of memories from the past
anterograde amnesia
inability to create new memories
Hebb’s rule
states that when two neurons are repeatedly active at the same time, the connection between them strengthens. This principle underlies how neurons form associations and memories in the brain, helping us learn and remember by reinforcing connections between neurons that are frequently activated together.
semantic dementia
neurodegenerative disorder characterized by the loss of semantic memory (ability to understand and recall the meaning of words, concepts, and knowledge of the world). Often associated with temporal lobe damage
alzheimer’s disease
degenerative memory loss
damage is diffuse and wide spread in the brain
medial temporal lobes degenerate early
mild cognitive impairment
memory and cognitive impairments, but able to lead a normal life
a precursor to dementia/alzheimers
MRI and PET scans can reveal it
cognitive maps
mental representations or internal models of physical spaces, environments, or spatial relationships. They allow individuals to navigate, orient themselves, and understand the layout of spaces without direct sensory input.
grid cells
found in the entorhinal cortex
fire in a hexagonal formation
play a role in path integration, updating an organism's position based on self-motion cues, and creating a spatially organized representation of the environment.
relational memory theory
proposes that memory is not just about storing isolated facts or items but also about encoding and retrieving the relationships and connections between these items.
simple model of episodic memory
encoding —> storage —> retrieval —> autonoetic consciousness —> reconstructive nature
subsequent memory task
a research methodology used in cognitive neuroscience and psychology to investigate the neural processes and brain mechanisms underlying memory encoding. It involves presenting participants with stimuli (such as words, images, or videos) and then assessing their memory for those stimuli at a later time.
Dorsal attentional control system
endogenous attention
supports attentional focus - maintains attention
intraparietal sulcus, superior parietal lobe, frontal eye fields
Ventral attentional control system
exogenous system
alerts to salient stimuli outside of attentional focus
disengages from current attentional focus and reorients
Endogenous attention
voluntary
directed by mind, not stimuli
highly focused
Exogenous attention
reflexive
comes from outside of mind
alerts us to important changes in the world
Spatial neglect
neglect of left side of space
occurs across sensory modalities
RH damage to frontal and parietal lobes
deficit in attention not perception
Phrenology
pseudoscience popular in the 19th century that proposed a relation to shape and size of bumps or contours in the skull and mental faculties or personality traits
Implicit memory
the use of stored knowledge without awareness of its use or effort in recollection (assisted by previous experience).
premotor theory of attention
Suggests that shifts of attention and preparation of goal-directed actions are closely linked
Suggests that a covert shift of attention is similar to a saccadic eye movement, but without the eye movement
capacity limits in attention
The focus is regarded as having a limited capacity and holds up to four of the activated representations.
N400
semantic anomalies
Perception of Anomalous words yields a Negative response 400ms after word begins
LAN
ERP response to Syntactic Violations
P600
ERP response for Syntactic Anomalies
Dual system of cognition
Hot and cold system
Saliency Map
a theoretical idea for predicting direction of eye movements and attention
Some parts of an image attract attention more effectively than others.
a bottom-up map of the relative interest of scene regions. Neural locus: Superior Colliculus, Pulvinar
Priority Map
Where we choose to move our eyes or covertly direct our attention depends on: stimulus saliency, our goals/values, where we have already looked
Intraparietal sulcus
Change Blindness
Exogenous Distractors Mask Other Exogenous Cues
To see an object change we must attend to it!
Inattentional Blindness
Salient stimuli can go undetected
Highly focused (endogenous) attention blocks out other salient (exogenous) stimuli
Go signal
the neural signal that initiates and coordinates voluntary movements. Typically originates in the primary motor cortex or the supplementary motor area
Mirror Neurons
Important in empathy; fire in response to watching someone else do something, as well as doing it yourself
Split brain surgery
severing of the corpus callosum to treat severe epilepsy.
Barlows neuron doctrine
neurons are information processing units
Sparse coding- neurons in the brain are selectively responsive to specific features
the brain reduces redundancy in neural activity
neural representations in the brain are optimized for efficiency
neural plasticity
Marr’s 3 levels of explanation
computational - what
algorithmic - how
Implementation - hardware/neurological
Phineas Gage
Damage to Left OrbitoFrontal Cortex & Medial PFC
Had trouble interacting with others
Behaved unethically
Belmont Report
guidelines for conducting ethical research on human subjects
respect for persons, beneficence, and justice
Causal Research methods
research for investigating the cause-and-effect relationship between variables
Correlational research methods
seeks to identify patterns and connections between variables
Ventral-Dorsal
“stomach”-”back”
Anterior-Posterior
front - behind
Medial-Lateral
close to center- away from center
Rostral-Caudal
front of head - back of head
Ventral Striatum
involved in reward processing
involved in motivation and goal-directed behavior
involved in learning associations between stimuli and rewards
contributes to emotional processing
dysfunction leads to addiction and impulsive behaviors
Implicit Bias
An unconscious attribution of particular qualities (stereotypes) to a member of certain social group
Implicit Associations Test
Caucasian vs. African American Faces
Positive or Negative words / traits
Logic is similar to Stroop Test (RT differences)
RH temporal parietal junction
theory of mind
social cognition (empathy, moral reasoning, social decision making, social judgements)
self-other distinction
attention and salience detection
Orbitofrontal damage
impaired decision making
social and emotional dysfunctions
risky behavior
social inhibition and disinhibition
personality changes
executive functioning deficits
PTSD
Extinction is impaired. Even when a stimulus no longer predicts a shock, it still yields a response; in skin responses, amygdala, and and vmPFC.
Inhibitory control of action
PFC (dlPFC)
Anterior cingulate
Inferior frontal gyrus
Basal ganglia
SMA
Frontoparietal network
Thalamus
brainstem
Stroop effect
Color naming task where word reading is automatic but color naming is more novel/less practiced