Gentics and Genomics

what is genetics

Study of genes and their role in inheritance

what is genomics

Study of how genes interact and influence people’s biologic and physical characteristics

what is pharmacogentics

Study of variability of drug metabolism related to variations in single genes

what is pharmacogenomics

Study of variability of drug metabolism in relation to variations in and interactions of multiple genes or the person’s genome

what are autosomal dominat Inhertited disorders

Males and females are affected, or have the disease, equally

• More common than recessive disorders and usually less severe

• Affected persons show variable expression (penetrance) and may have an affected parent

• Children of a heterozygous (affected) parent have a 50% chance of being affected

• Persons are affected in successive generations

what are autosomal recessive interited disorders

Males and females are affected equally

• Heterozygotes are carriers and usually asymptomatic

• Affected persons may have unaffected parents who are heterozygous for trait

• Children of 2 heterozygous parents have a 25% chance of being affected and a 50% chance of being carriers

• Often no family history of disease

what are x-linked disorders

• Most affected persons have unaffected parents

• Affected persons are usually male

• Daughters of affected males are carriers

• Sons of affected males are unaffected (unless mother is a carrier)

what are Y linked disorders

Affected fathers transmit only to sons