MUSCARINIC ACETYLCHOLINE RECEPTOR DRUGS

Methacholine

mAChR AGONISTS: choline ester mAChR agonist

Carbachol

mAChR AGONISTS: choline ester mAChR agonist

Bethanechol

mAChR AGONISTS: choline ester mAChR agonist

Muscarine

NAT URALLY OCCURING

Cevimeline

NATURALLY OCCURING: M3 specific mAChR agonist - naturally occuring cholinomimetic alkaloids

Pilocarpine

NATURALLY OCCURING: mAChR agonist - naturally occuring cholinomimetic alkaloids

Atropine

muscarine antagonist (natural):

Scopolamine

muscarine antagonist (natural):

Ipratropium

semi synthetic derivative of atropine → muscarinic antagonist

Tropicamide

synthetic muscarinic antagonist

Cyclopentolate

synthetic muscarinic antagonist

Solifenacin

M3 selective synthetic muscarinic antagonist

Darifenacin

M3 selective synthetic muscarinic antagonist

Pirenzipine

M1 selective synthetic muscarinic antagonist

MT7 (snake)

M1 selective synthetic muscarinic antagonist

Hyoscine butylbromide

anti-spasmodic GI tract drug via M3/M2 synthetic antagonism

Tiotropium

long acting muscarinic synthetic antagonist

Glycopyrronium

muscarinic synthetic antagonist → prevent excess salivation

Edrophonium

non-covalent reversible short-acting AChE inhibitor

Neostigmine

covalent reversible medium-acting AChE inhbitor

Organophosphates (e.g. sarin)

non-reversible AChE inhibitor

Physostigmine

non-charged reversible, medium-acting AChE inhibitor

Pralidoxime

performs a nucleophilic attack to remove the phosphate group from the serine to free the enzyme → reactivates AChE