gi exam 1 drugs

lansoprazole brand

prevacid

lansoprazole class

ppi

lansoprazole moa

proton pump inhibition

lansoprazole AEs

increased incidence of osteoporosis-related bone fractures of the hip, spine, or wrist; may diminish the therapeutic effect of clopidogrel; increased risk of c diff

lansoprazole dose

15-30 mg po qd

lansoprazole contraindications

hepatic (consider dose adjustment with severe impairment)

lansoprazole BBW

none

dexlansoprazole brand

dexilant

dexlansoprazole class

ppi

dexlansoprazole moa

proton pump inhibition

dexlansoprazole AEs

increased incidence of osteoporosis-related bone fractures of the hip, spine, or wrist; may diminish the therapeutic effect of clopidogrel; increased risk of c diff

dexlansoprazole dose

healing: 60 mg po qd x up to 8 weeks maintenance: 30 mg po qd

dexlansoprazole contraindications

hepatic (consider dose adjustment with severe impairment)

dexlansoprazole BBW

none

pantoprazole brand

protonix

pantoprazole class

ppi

pantoprazole moa

inhibits gastric cell hydrogen-potassium ATPase

pantoprazole AEs

diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, vertigo, myalgia

pantoprazole dose

20 mg PO/IV qd

pantoprazole contraindications

none

pantoprazole bbw

none

omeprazole brand

prilosec

omeprazole class

ppi

omeprazole moa

inhibits gastric cell hydrogen-potassium ATPase

omeprazole dose

20 mg PO qd

omeprazole AEs

diarrhea, headache, abdominal pain, nausea, flatulence, dizziness, rash, upper respiratory infection

omeprazole contraindications

none

omeprazole bbw

none

esomeprazole brand

nexium

esomeprazole class

ppi

esomeprazole moa

inhibits gastric cell hydrogen-potassium ATPase

esomeprazole AEs

diarrhea, headache, abdominal pain, nausea, vomiting, flatulence, dizziness

esomeprazole dose

20-40 mg PO QD

esomeprazole contraindications

none

esomeprazole bbw

none

famotidine brand

pepcid

famotidine class

histamine blocker (h2)

famotidine moa

antagonizes H2 histamine receptors

famotidine dose

20-40 mg po qd

famotidine AEs

dizziness, headache, taste changes, constipation, diarrhea

famotidine bbw

none

famotidine contraindications

none

ibuprofen brand

advil, motrin

ibuprofen class

nsaid

ibuprofen moa

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

ibuprofen dose

peds: 5-10 mg/kg q 6-8hrs adult: 300-800 mg tid-qid

ibuprofen AEs

dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity

ibuprofen contraindications

ASA/nsaid induced asthma, 2nd/3rd trimester of pregnancy, CABG side effects

ibuprofen bbw

may increase risk of CV thrombotic events, may increase risk of fatal GI events

meloxicam brand

mobic

meloxicam class

nsaid

meloxicam moa

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

meloxicam dose

7.5-15 mg po qd

meloxicam AEs

dyspepsia, nausea, abdominal pain, dizziness, headache, rash, constipation, edema

meloxicam contraindications

aspirin/nsaid allergy, pregnancy, 2nd/3rd trimester

meloxicam bbw

may increase risk of cv thrombotic events, may increase risk of fatal GI events

naproxen brand

naprosyn naprelan

naproxen class

nsaid

naproxen moa

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

naproxen dose

IR/DR: 250-500 po q12hr ER: 750-1000 mg po qd

naproxen AEs

dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity

naproxen contraindications

ASA/NSAID induced asthma, 2nd/3rd trimester of pregnancy, cabg side effects

naproxen bbw

may increase risk of CV thrombotic events, may increase risk of fatal GI events

celecoxib brand

celebrex

celecoxib class

cox-2 inhibitor

celecoxib moa

selectively inhibits cox-2 and reduces prostaglandin synthesis

celecoxib dose

100-200 mg po qd-bid

celecoxib AEs

headache, diarrhea, nausea, vomiting, peripheral edema, photosensitivity

celecoxib contraindications

hypersensitivity to sulfonamides, pregnancy after 1st trimester

celecoxib bbw

may increase risk of cv thrombotic events, may increase risk of fatal gi events

diclofenac brand

voltaren

diclofenac class

nsaid

diclofenac moa

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

diclofenac dose

DR: 50 mg po bid-tid ER: 100 mg po qd

diclofenac AEs

dyspepsia, vomiting, headache, dizziness, rash, drowsiness, fluid retention

diclofenac contraindications

aspirin or nsaid allergy, pregnancy 2nd or 3rd trimester

diclofenac bbw

may increase risk of cv thrombotic events, may increase risk of fatal GI events

ketorolac brand

toradol, sprix

ketorolac class

nsaid

ketorolac moa

inhibits cyclooxygenase, reducing prostaglandin and thromboxane synthesis

ketorolac dose

10 mg po q4-6hrs prn

ketorolac AEs

GI bleeding, perforation, or ulcer, dyspepsia, nausea, abdominal pain, constipation, headache, drowsiness, photosensitivity

ketorolac contraindications

major surgery pre-op, ASA/NSAID induced asthma, epidural or intrathecal use, CABG Sx

ketorolac bbw

oral - up to 5 days treatment and only after parenteral use all - may increase risk of CV thrombotic events; may increase risk of fatal GI events