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Lectures 10-15
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True or false: Autonomic motor neurons do not directly innervate target cells.
True
Which neurons are involved in an autonomic motor pathway?
A preganglionic and postganglionic neuron
True or false: The two neurons of the autonomic nervous system synapse in the autonomic ganglion in the PNS.
True
Which neurotransmitters are released by the autonomic nervous system?
Acetylcholine (ACh) and norepinephrine (NE)
True or false: The autonomic nervous system controls vital functions such as heart rate, blood pressure, and digestive and urinary processes.
True
True or false: The autonomic nervous system operates without conscious control.
True
Which does the autonomic nervous system function through?
Visceral reflex arcs
Which regions of the spinal cord do preganglionic neurons of the sympathetic nervous system originate in?
Thoracic and lumbar spinal cord (Thoracolumbar division)
Which is the name for the location of sympathetic postganglionic cell bodies?
Sympathetic chain ganglia
Which is the location of sympathetic chain ganglia?
Near the spinal cord along the vertebral column
Which regions of the spinal cord do preganglionic neurons of the parasympathetic nervous system originate in?
Cranial nerves of the brainstem and sacral spinal cord (Craniosacral division)
Which is the location of postganglionic neurons of the parasympathetic nervous system?
Ganglia near or within the target organs
Which neurotransmitter do both divisions of the autonomic nervous system release from preganglionic axons?
Acetylcholine (ACh)
Which receptor does ACh bind to on postganglionic neurons?
Nicotinic receptors
Which neurotransmitter do parasympathetic postganglionic neurons release?
Acetylcholine (ACh)
Which receptors does parasympathetic postganglionic ACh bind to on target cells?
Muscarinic receptors
Which neurotransmitters do most sympathetic postganglionic neurons release?
Norepinephrine (NE) or epinephrine (E) (adrenergic fibers)
Which receptors do NE and E bind to on sympathetic target cells?
Adrenergic receptors
True or false: Some sympathetic postganglionic neurons release ACh, which binds to muscarinic receptors (cholinergic fibers).
True
Which cranial nerves are associated with the parasympathetic nervous system?
Oculomotor (III), Facial (VII), Glossopharyngeal (IX), and Vagus (X)
Which sacral nerves are associated with the parasympathetic nervous system?
S2–S4 which form the pelvic splanchnic nerves
Parasympathetic branches form plexuses in and synapse in:
Terminal ganglia near target organs
Which is an autoimmune disorder that attacks the myelin sheath around CNS axons?
Multiple Sclerosis
Which is a disorder associated with the degeneration of α-motor neuron cell bodies in the anterior horn of the spinal cord and upper motor neurons of the cerebral cortex?
Lou Gehrig’s Disease (ALS)
Which is the correct order of the process of sensation?
Stimulus is detected by sensory receptors of the PNS
The signal is transmitted by PNS sensory neurons to the CNS
The signal is integrated and interpreted by CNS neurons
Which are general senses?
Touch, temperature, and pain
Which detects the general senses?
Receptive endings of sensory neurons
Which transmits the general senses?
Spinal and cranial nerves
Which are special senses?
Light, sound, head movement, smell, and taste
Which detects the special senses?
Specialized cells, except for in olfaction
Which transmits the special senses?
Cranial nerves
True or false: All senses are detected by specialized cells.
False, olfaction receptors are neurons
Which refers to the conversion of a stimulus into electrical signals?
Sensory transduction
Which is the correct order of the events of sensory transduction?
Ion channels are closed at rest
Mechanically gated Na⁺ channels open, causing receptor potential
If the threshold is reached, voltage-gated Na⁺ channels open, triggering an action potential.
True or false: Ion channels of sensory receptors are closed at rest.
True
Which type of ion channels open during transduction to cause receptor potential?
Mechanically gated Na⁺ channels
Which triggers the action potential in sensory transduction?
Opening of voltage-gated Na⁺ channels
Which location of stimuli do exteroceptors detect?
External stimuli like light, texture, and temperature
Which location of stimuli do interoceptors detect?
Internal stimuli like blood pressure and organ stretch
Which type of stimuli do mechanoreceptors detect?
Physical deformation
Which type of stimuli do thermoreceptors detect?
Thermal stimuli
Which type of stimuli do chemoreceptors detect?
Chemical stimuli
Which type of stimuli do photoreceptors detect?
Light stimuli
Which type of stimuli do nociceptors detect?
Pain
Which type of adapting receptors respond quickly but stop signaling during continuous stimulation?
Rapidly adapting receptors
Which is an example of a rapidly adapting receptor?
Lamellated (Pacinian) corpuscles
Which type of adapting receptors maintain signaling during continuous stimulus?
Slowly adapting receptors
Which is an example of a slowly adapting receptor?
Ruffini endings
Which describes when light rays from distant objects are nearly parallel and focus on the retina with minimal lens refraction?
Emmetropic state
Which describes when the lens rounds up to increase refraction for focusing on nearby objects?
Accommodation
Which structure performs most of the eye’s refraction?
Cornea
Which structure adds more refraction in focusing light, especially during accommodation?
Lens
Which describes how the shape of the lens changes during distant vision?
The ciliary body relaxes and suspensory ligaments tighten to flatten the lens
Which describes how the shape of the lens changes during near vision?
The ciliary body contracts and suspensory ligaments loosen to round the lens
Which condition is caused by stiffening of the lens, reducing accommodation, with age?
Presbyopia
Which condition is caused by an eyeball that is too short or a cornea that is too flat?
Hyperopia (farsightedness)
Which is the location of the image focused in hyperopia (farsightedness)?
Behind the retina
Which type of lens corrects hyperopia?
Convex
Which condition is caused by an eyeball that is too long or a cornea that is too curved?
Myopia (nearsightedness)
Which is the location of the image focused in myopia (nearsightedness)?
In front of the retina
Which type of lens corrects myopia (nearsightedness)?
Concave
Which condition is caused by irregular curvature of the cornea or lens, leading to uneven refraction?
Astigmatism
Which are the CNS regions associated with the special sense vision?
Information travels to the primary visual cortex via the optic nerve
Which are the CNS regions associated with the special sense hearing in the auditory pathway?
Cochlear nerve → Vestibulocochlear nerve → Cochlear nucleus (medulla-pons junction) → Superior olivary nucleus (pons) → Inferior colliculus (midbrain) → Medial geniculate nucleus (thalamus) → Primary auditory cortex (temporal lobe)
Which are the CNS regions associated with the special sense equilibrium in vestibular sensation?
Travels through the vestibulocochlear nerve and targets vestibular nuclei in the brainstem, thalamus, cerebellum, spinal cord, and oculomotor control nuclei
Which are the CNS regions associated with the special sense olfaction?
Olfactory bulb → Primary olfactory cortex (temporal lobe)
True or false: The olfactory pathway synapses in the thalamus.
False
Which are the additional CNS regions associated with the integration of the special senses olfaction and gustation?
Amygdala, Hippocampus, Hypothalamus, and Frontal lobe
Which are the CNS regions associated with the special sense gustation?
Signals are carried via the Facial nerve (VII), Glossopharyngeal nerve (IX), and Vagus nerve (X) to brainstem nuclei
Which are the layers of the retina?
Outer pigmented epithelium and inner neural layer
Which types of cells are found in the inner neural layer of the retina?
Photoreceptors and neurons
Which are the cylindrical outer segments of photoreceptors?
Rods
Which are the conical outer segments of photoreceptors?
Cones
Which pigment do rods contain?
Rhodopsin (opsin + retinal)
Which pigment do cones contain?
Iodopsin (photopsin + retinal)
Which photoreceptor functions best in dim light?
Rods
Which photoreceptor functions best in bright light and color vision?
Cones
Which photoreceptor is highly concentrated in the fovea centralis of the retina?
Cones
Which state is rhodopsin in in darkness?
Intact as opsin + cis-retinal
Which is the correct order of transduction of photoreceptors in the dark?
cGMP keeps Na⁺ channels open → depolarization → continuous neurotransmitter release
Which molecule keeps Na⁺ channels open in dark-adapted photoreceptors?
cGMP
Which is the result of Na⁺ channels being open in the dark?
Depolarization and continuous neurotransmitter release
Which is the correct order of transduction of photoreceptors in the light?
Retinal changes to trans-retinal → rhodopsin bleaches → activates transducin → activates PDE → cGMP → GMP → Na⁺ channels close → hyperpolarization → neurotransmitter release reduced
Which happens to retinal in light?
It converts to trans-retinal
Which happens when rhodopsin is bleached by light?
It activates transducin
Which is activated by transducin?
Phosphodiesterase (PDE)
Which describes the role of PDE in phototransduction?
Converts cGMP to GMP
Which happens when cGMP levels fall?
Na⁺ channels close
Which is caused by the closing of Na⁺ channels?
Hyperpolarization and reduced neurotransmitter release
Which describes transduction in photoreceptors as they adapt to darkness?
Rods regenerate rhodopsin slowly, taking up to 40 minutes
Which describes transduction in photoreceptors as they adapt to light?
Rods are quickly bleached and cones adapt within minutes
Which describes how photoreceptors synapse for image processing in the retina?
Synapses with bipolar cells → retinal ganglion cells
Which describes how the fovea centralis synapses for image processing in the retina?
Synapses with each cone → 2 bipolar cells → 1 ganglion cell → sharp vision
Which cells modulate signals between photoreceptors and bipolar cells?
Horizontal cells
Which cells modulate signals along the dendrites of ganglion cells?
Amacrine cells
Which cells do photoreceptors synapse with?
Bipolar cells
Which cells do bipolar cells synapse with?
Retinal ganglion cells
Which describes how cones connect to bipolar and ganglion cells in the fovea centralis?
Each cone connects to 2 bipolar cells and 1 ganglion cell
Which regions of the central nervous system does visual stimuli travel to?
Sent from photoreceptors of the retina through the optic nerve and to the brain for conscious awareness and interpretation
Which is the correct order of the transmission of sound in the inner ear?
Sound waves are funneled into the auditory canal → strike the tympanic membrane → ossicles → oval window → generate waves in the perilymph of the scala vestibuli and endolymph of the cochlear duct → basilar membrane vibrates for hearing