Microbiology Lecture 4.24: Clostridium tetani
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12 Terms
Where are C. tetani ubiquitous?
Soil
Is C. tetani exposure common?
Yes
Is disease caused by C. tetani common in vaccinated populations?
No
What is the virulence factor of C. tetani?
Tetanospasmin (Neurotoxin)
Where is Tetanospasmin (Neurotoxin) transported?
Inhibitory neurons in CNS
What does the A subunit of Tetanospasmin (Neurotoxin) block?
Release of inhibitory neurotransmitters
What is caused when the release of inhibitory neurotransmitters is blocked by Tetanospasmin?
Uncontrolled muscle contraction
What do C. tetani enter in humans?
1. Puncture wounds
2. Contaminated injuries
3. Crush injuries
4. Necrotic tissue
What are the classic signs of C. tetani infections?
1. Trismus (Lockjaw)
2. Persistent back spasms
What are the signs of C. tetani infection in neonates?
Umbilical stump infection
What is the treatment method for C. tetani to neutralize the circulating toxin?
Passive immunization with antitoxin
What is the prevention method for C. tetani?
Tetanus toxoid vaccine
Note 
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