Protein-Synthesis active and other

Aminogylcosides “cin” types (3)

Gentamincin + BLI

Tobramycin

Amikacin

Aminogylcosides mech

Binds to 30s ribosomal subunits, causes decrease in protein synthesis, leads to increase in misreading of mRNA

BacteriCIDAL

Gram (-) aerobic → pseaudomas

can be paired with vanco to treat MSSA, MRSA< enterococcus

D - vascular and interstitial spaces, urine

E - haft life = 1-72 hr, 100% excreted by kidneys

Aminogylcosides treat

Gram -

can be paired with vanco to treat MSSA, MRSA< enterococcus

Pseudomonas

Aminogylcosides ADR

Nerphrotoxicity

ototoxicity

GET levels!

Aminogylcosides cautions

Preg - D class

Peds - dose mg/kg - changes frequently

Geriatrics - dose cafefully

renal - dose by levels

Tetracyclines kinds, mech

All end in cycline

Tetracyline, minocycline - Advoid in pt with renal

Doxycycline - most commonly used

Binds to 30s

BacterioSTatic

Gram + and - EXCEPT pseudomas

D - synovial fluids, mucosa, bile

E - Haft life 8-16 hrs

Tetracyclines treat

MRSA cellulitis - Doxy - PO !!

Chlaymidia - first line

Rocky Mountain spotted fever

Lymes

Tetracyclines ADR

Hypersensitivity

Photosensitive

Decrease in skeletal growth in kids

Teeth staining

Note: oral absorption decreased with milk and antiacids

Esophageal irritation!!! → drink lots of water and no laying down right after taking

Tetracyclines Cautions

Preg - class D

Peds - effect on teeth

Renal watch levels

Macrolides types

All end in thromycin

Erythromycin

Azithromycin

Clarithromycin