Pentose Phosphate Pathway in Medical Biochemistry

These flashcards cover key concepts related to the Pentose Phosphate Pathway and Uronic Acid Pathway discussed in the Medical Biochemistry lecture.

What is the alternative name for the Pentose Phosphate Pathway?

Hexose Monophosphate (HMP) shunt.

What are the two major functions of the Pentose Phosphate Pathway?

1. Formation of NADPH 2. Synthesis of ribose 5-phosphate.

What is the rate limiting enzyme of the oxidative part of the Pentose Phosphate Pathway?

Glucose 6-phosphate dehydrogenase (G6PDH).

Where does the Pentose Phosphate Pathway primarily occur?

In the cytoplasm of all cells.

Which key product of the Pentose Phosphate Pathway is used in nucleotide synthesis?

Ribose 5-phosphate.

What role does NADPH play in cells?

It is used in biosynthesis, maintenance of reduced glutathione, and bactericidal activity.

What does the non-oxidative part of the Pentose Phosphate Pathway produce?

Fructose-6-phosphate and Glyceraldehyde-3-phosphate.

Which pathway is an alternative oxidative pathway for glucose and occurs in the liver?

Uronic acid pathway.

What condition is associated with a deficiency of glucose-6-phosphate dehydrogenase?

Hemolytic anemia and Favism.

What are Heinz bodies and in which condition are they typically found?

Heinz bodies are precipitated hemoglobin and are typically found in G6PD deficiency.