ME: Embryonic period wk 3-8

What initiates the formation of the neural plate from the ectoderm?

signals from notochord and prechordal mesoderm

Which molecule inhibits BMP4 and promotes neural tissue formation?

chordin, jogging, and follistatin

Which region of the neural tube becomes the brain

the cranial anterior part

what are the four stages of neurluation

1. neural plate forms

2. neural folds → neural groove

3. neural folds fuse

4. neural tube seperates from surface ectoderm

what structure do neural crest cells arise from

lateral borders (crests) of the neuroectoderm

name 3 derivatives of neural crest cells

• melanocytes

• craniofacial cartilage/bone

• peripheral neurons

what are major neural tube defects cause by failure of neural tube closure

• anencephaly

• spina bifida

• (total) rachischisis

• encephalocoele

how can neural tube defects be preveneted in many cases

folid acid (moet genomen worden voor conception en early pregnancy, dus is geen geneesmiddel)