Neurophysiology of Pain

central sensitization pain (nociplastic)

pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain

nociceptive pain

history of damage to body tissue

neuropathic pain

lesion or disease of NS causing pain

cartesian model of pain

nerves described as hollow tubes

fiber activated by tugging on cord causing bell attached to ring (tugging perception felt in brain)

religious beliefs that associated pain w/ punishment

input mechanisms

various forms of info sent to spinal cord and brain

info from tissues, environmental influences, and peripheral NS

processing mechanisms

structures and processes inside the CNS and brain processing the info from the input mechanisms and forming a conclusion

include cognitive and emotional aspects

output mechanisms

brains interpretation of info

includes various biological systems and strongly driven by instincts to survive in relation to pain experience

mature organism model

tissue contribution

positive/negative influences of environment

PNS inputs and transmission up SC

how brain process this info

output mechanisms that respond to threat analysis