Cellulose and collagen quiz

what are plants ECM made up of

polysaccharides

what are animal ECM made up of

collagen

Where are epithelial cells located compared tothe ECM, fibroblasts

epithelial rests on top

fibroblast seated within

what does the ECM influence

cell diviion, shape, differentiation, support

Many ECM components bind receptors on the cell surface This initiates

intracellular signaling events

what gives the plant cell wall tensile strength

cellulose

what provides animal cells tensile strength

collagen fibers

what are integrins

transmembrane proteins that bind to ECM components

couple matrix outide cell to cystoskeleton inside

what makes up ground substance

gels of polysaccharides and proteins

what is the outer layer of the plant cell wall, inner

outer: pectin

inner: cellulose (rigid and thick)

what linkages create cellulose molecule

B 1-4- linkage

how many collaen molecules make up a microfibril, what type of bond

16 cellulose molecules

H-bond (non-covalent)

what are short chains called, long chains

oligosaccharides

polysaccharides

what do ligins do

rigidity and waterproofing

where is cellulose produced

outside cell wall in the ECM (not exocytosis)

what is found in the middle lamella, primary cell wall

middle- pectin

primary- cellulose, hemicellulose, pectin

dermis is

hard and dense is

soft, transparent is

resilient and shock absorbing is

skin

bone/teeth

eye

cartilage

Whatare bones made out of, skin/tendons

osteoblasts

fibroblasts

What is the ECM made up of

fibrous and ground substance

what is elastins role

to stretch and then recoil like a spring, restoring the original shape of the tissue

what does matrix metalloproteinases do

digest ECM

what are the organization levels of collagen

single strand

triple uncleaved strand

triplestrand

collagen fibril

collagen fiber

how are collagen fibers layed down

at right angles with fibroblasts in between

what protein cleaves terminal procollagen

proteinase

can collagen self assemble into fibrils

yes

where is procollagen secreted from

vesicles made in the golgi

whatlinks collagen to cellular receptors

fibronectin

what provides functional units

several domains

what are the jobs of intergins

connect the ECM to the cytoskeleton

what are two proteins that connect the integrins to actin

talin and alpha actinin

what makes up a fibronectin

collagen binding site

cell attachment site

how can an alpha and beta subunit be activated

outside-in activation

inside-out activation

whathappens to integrin when it becomes active

it grows

strong binding to ECM and cytoskeleton occurs

what is laminin

tracksthat help migrate cells

often seen in embryonic stage

What is GAG made of

repeating disaccharide

what are bones and tendons made of

small proportion GAG, mostly collagen

what is the eye made of

mostly one king of GAG, little collagen

what makes up hyaluronic acid

suagr: N-acetylglucosamine

Uronic acid: glucuronic acid

what are GAGs linked to core proteins

proteoglycans

what does proteoglycans do

form gels with pores

binds growth factors

block, guide, encourage cell migration

affect cell behavior

in repeating disaccharide units, what are the acids and bases

acid: COOH

Base: OH

what makes the disaccharide hydropgilic

COO-, makes it moisturized