Clostridioides difficile
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13 Terms
What is the gram characteristic of Clostridioides difficile?
Gram positive
T/F Clostridioides difficile is spore forming?
True
T/F Clostridioides difficile is motile?
False
Where are the spores for Clostridioides difficile?
Large and Central
What disease does C. difficile cause?
Enterocolitis
What is the cause of enterocolitis in horses?
Overgrowth of C. difficle in the colon
What are the 2 major risk factors of enterocolitis in horses?
Antibiotic use with broad-spectrum
Hospitalization
What are the clinical signs to enterocolitis in horses?
Profuse watery diarrhea
Very similar to Salmonella or C. perfringens
What do foals get when the get enterocolitis?
Hemorrhagic necrotizing enterocolotis
How do you treat entercolotis in horses?
Vancomycin or metronidazole
What are the 2 main virulence factors of C. difficile?
Toxin A: Enterotoxin
Toxin B: Cytotoxin
What does enterotoxin do?
Causes fluid accumulation (diarrhea)
T/F hypervirulent strains exist?
True
Note 
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