Obih and Horani Drugs

What Drug can be used to oppose histamine Bronchoconstriction

Epinephrine

Which Drug( s) inhibit the release of histamine?

Cromolyn AND Nedocromil

H1 receptor antagonist are ___________ blockers or _______ agonist to the H1 receptor

Competitive; Inverse

T/ F Antihistamines antangonize bronchiolar constriction from leukotrienes and histamine

F

T/F Antihistamines are efficaous enough to treat asthma attacks

F; they act too slow

List the First Generation Antihistamines that derive from the chemical class Ethanol-amines

DIphendydramine- Benadryl

Clemastine - Tavist

List the First Generation Antihistamines that derive from the chemical class Ethelenediamine

Tripelennamine

List the First Generation Antihistamines that derive from the chemical class Alkylamine

Chloropheniramine - Chlorotrimeton

List the First Generation Antihistamines that derive from the chemical class Phenothiazine

Promethazine -Phenergan

List the First Generation Antihistamines that derive from the chemical class Piperazine

Hydroxyzine -Vistaril

Cyclizine- Antivert

The active metabolite of Hydroxiyzine is _________

Certrizine

The active metabolite of loratadine is__________

Desloratadine

T/F First generation H1 antagonist can stimulate and depress the CNS

T

List Sedative H1 antagonists

Promethazine ( Phenergan)

Diphenhydramine ( Benadryl)

List anti-nausea antihistamines

Doxylamine

Promethazine

Scopolamine

List antiparkinson antihistamine

Which subgroups of the first generation antihistamines have anti-muscarinic effects , list the drugs within both the groups.

What’s the drug with the strongest of the effects?

Ethanolamine:

• Diphenhydramine, Clemastine

Ethylenediamine:

• Tripelenamine,

Promethazine is the strongest

Which drugs have a significant atropine effect?

The same that have antimuscrinic effects. Study those

List H1 antagonist that demonstrate alpha -receptor blacking effects

Drugs Within the Phenothiazine Group

• Promethazine

Antihistamines within the __________ subgroup can cause orthostatic hypotension in susceptible individuals.

Phenothiazine

List the H1 antihistamine with serotonin- blocking actions.

Cyproheptadine

List H1 antagonist that have local anesthetic effects

Promethazine

Dimenhydrinate

Many _______ generation H1 antagonist exhibit mast-cell stabilizing effects.

2nd

List the antihistamine approved for Rhinorrhea

Clemastine

List the antihistamine approved for allergic dermatoses

Diphenhydramine

List the two main indications that 2nd generation H1 antagonists treat

1. Allergic Rhinits

2. Chronic Uticaria

List the antihistamine MOST EFFECTIVE for the prevention of motion sickness

Dimenhydrinate

Name the antihistamine that is used to treat MORNING SICKNESS

Doxylamine

WHat the four manifestations to Anticholinergic drugs

Dry mouth, Constipation, Blurred Vision, and urinary retention

T/F 2nd generation H1 antagonists have poor affinity for muscarinic cholinoceptor

T

Lost the two reasons 2nd generation H1 antagonist reduce the occurrence of sedation

1. Lipophobicity

2. They’re substrates of P-glycoprotein, keeping them from the BBB and staying plasma

T/F 2nd generation. Antihistamines have the same efficacy as 1rst generation

T

T/ F 2nd generation antihistamines are highly selective to H1 receptors

T

_____________ is the safe metabolite of Terfenadine. What the brand name?

Fexofenadine; Allegra

This anithistmine is used to treat hay fever ( allergic rhinitis)

Allegra

Claritin and Clarinex derive from _________

Azatadine

Which Antihistamine is used to treat rash/hives? What’s the Brand Name(s)

Cetirizine( Zyrtec) and Levocetirizine(XYZAL)

Zyrtec and XYZAL derive from ________

Hyroxyzine

__________ is the main 2nd generation H1 antagonist that has sedative effects

Zyrtec ( Cetirizine)

Out of all the 2 generations derived from Hydroxyzine _________ is the most potent

Levocetirizine

Generic for Semprex- D

Acrivastine

Which anithistamine increases appetite

Antiserotinin agents; Cyproheptadine

Which antihistamines are treated for migraines ?

Cyrpoheptadine

Ergotamine

Diphenhydramine

Which antihistamines are treated for Nausea ad Motion Sickness?

Dimenhydrinate ( salt of diphenhydramine

Diphenhydramine

Cyclizine

Meclizine

Promethazine

Which antihistamines are treated for Insomnia

Diphenhydramine, Promethazine, Pyrilamine

Which antihistamines are treated for General itching

Hydroxyzine, Doxepin.

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