Hematology Quiz 8

Lymphoproliferative disorder definition

clonal, malignant proliferation of B/T lymphocytes

Cause of Chronic Lymphocytic leukemia

clonal proliferation of B lymphocytes

Cells associated with CLL

mature lymphs, smudge cell

Smudge cell composition

lymphocyte chromatin

Key morphology of HCL

hairy cell

Diagnostic test for Hairy Cell Leukemia

trap stain

Key symptoms of Hair Cell Leukemia

dry tap

Treatment for Hair Cell leukemia

splenectomy, pentastain for apoptosis

Basis of diagnosis for Hodgkin’s Lymphoma

biopsy

Key cell of Hodgkin’s Lymphoma

reed-sternberg

Why is non-hodgkin’s lymphoma worse

can be anywhere in the body

Predominant cell type of Multiple Myeloma

plasma cells

Most common demographic of Multiple myeloma

males

M:E ratio of CLL

10-20:1

Clinical pathways of Multiple myeloma

acceleration of plasma cells in bm, activation of bm resorption factors/osteoclasts, production of abnormal monoclonal protein

Cells seen with Acceleration of plasma cells in BM with MM

Russell bodies, flame cells, overcrowding

Clinical signs of Activation of bone resorption factors/osteoclasts in MM

serum calcium increased, severe bone pain and lytic lesions

Definition of Production of an abnormal monoclonal protein in MM

proliferation of IgG

Cells seen with Production of an abnormal IgG in MM and definition

rouleaux, non-specific binding of rbcs

ESR result with Production of an abnormal IgG in MM and definition

increased

Protein found in urine of patients w. MM

bence-jones

Meaning of having Bence-Jones protein in urine

kidney damage

CBC results of MM

pancytopenia

Protein electrophoresis result of MM

M spike

Significance of increased Serum beta microglobulin in MM

tumor burden worsens

Appearance of radiography with MM

punched out lesions

Primary complication of MM

plasma cell leukemia, increased plasma cells in blood

Antibody predominating in Waldenstrom’s Macroglobulinemia

IgM

How does increased IgM affect blood circulation

hyperviscosity

How does increased IgM interfere with coagulation factors

coating platelets, impeding function

Significant symptom of Waldenstrom’s Macroglubulinemia

neurologic

Preferred treatment for Waldenstrom’s Macroglobulinemia

plasmapheresis

Complications of CLL

BM involvement, immunodeficiency, autoimmune conditions, Herpes zoster

Cause of death with CLL

infection

Blast percentage range with Myelodysplastic Syndromes

5-20

Definition of Myelodysplastic syndromes

stem cell disorders that leads to the formation of abnormal hematopoietic clone

Most common type of Myelodysplastic syndrome

secondary to prior treatment

Dysplasia definition

abnormal development of tissue

Nucleus maturation affect of Myelodysplastic syndromes

asynchrony

Term associated with most Myelodysplastic syndromes

refractory

Major concern of Myelodysplastic syndromes

progression to acute leukemia