Unit 7: Disorders of Iron Metabolism

What are the 4 most common anemias caused by disorders of iron metabolism?

1. IDA

2. anemia of chronic disease

3. sideroblastic anemia

4. lead poisoning

Fe ++ is (ferrous/ferric) iron.

ferrous

Fe +++ is (ferrous/ferric) iron.

ferric

(Ferrous/Ferric) iron binds to the transport protein __________.

Ferric

transferrin

What is the storage protein for iron?

ferritin

Majority of iron in the body is in the form of ____________.

hemoglobin

What are the iron studies for IDA?

serum iron - decreased

ferritin - decreased

TIBC - increased

What are the iron studies for anemia of chronic disease?

serum iron - decreased

ferritin - normal/increased

TIBC - decreased

An increase in CRP and ESR is indicative of what anemia?

anemia of chronic disease

What are the iron studies for sideroblastic anemia?

serum iron - increased

ferritin - increased

TIBC - normal/decreased

Siderocytes/Pappenheimer bodies are made of:

non-heme iron

What stain is used to verify siderocytes?

Prussian blue

Basophilic stippling is characteristic of what iron metabolism disorder?

lead poisoning

What are the iron studies for lead poisoning?

serum iron - variable

ferritin - normal

TIBC - normal

Which anemia has red cell morphology similar to that seen in iron deficiency anemia:

• Sickle cell anemia

• Thalassemia syndrome

• Pernicious anemia

• Hereditary spherocytosis

Thalassemia syndrome

Which of the following parameters may be similar for the anemia of inflammation and iron deficiency anemia:

• Normocytic indices

• Decreased serum iron

• Ringed sideroblasts

• Pappenheimer bodies

Decreased serum iron

What is the basic hematologic defect seen in patients with thalassemia major:

• DNA synthetic defect

• Hgb structure

• Beta chain synthesis

• Hgb phosphorylation

Beta chain synthesis

The osmotic fragility test result in a patient with thalassemia major would most likely be:

• Increased

• Decreased

• Normal

• Decreased after incubation at 37 degrees C.

Decreased

Skeletal abnormalities and marrow hypertrophy are present in thalassemia major patients due to:

• Depletion of calcium

• Unbalanced globin chain production

• Erythropoietin deficiency

• Hypersplenism

Unbalanced globin chain production

Which of the following is the primary Hgb in patients with thalassemia major:

• Hgb D

• Hgb A

• Hgb C

• Hgb F

Hgb F