Unit 7: Disorders of Iron Metabolism

What are the 4 most common anemias caused by disorders of iron metabolism?

1. IDA

2. anemia of chronic disease

3. sideroblastic anemia

4. lead poisoning

Fe ++ is (ferrous/ferric) iron.

ferrous

Fe +++ is (ferrous/ferric) iron.

ferric

(Ferrous/Ferric) iron binds to the transport protein __________.

Ferric

transferrin

What is the storage protein for iron?

ferritin

Majority of iron in the body is in the form of ____________.

hemoglobin

What test is the indirect measurement of transferrin?

TIBC

What iron metabolism deficiency has these results:

serum iron: decreased

ferritin: decreased

TIBC: increased

IDA

What iron metabolism deficiency has these results:

serum iron: decreased

ferritin: increased

TIBC: decreased

anemia of chronic disease

What iron metabolism deficiency has these results:

serum iron: increased

ferritin: increased

TIBC: decreased

sideroblastic anemia

Siderocytes/Pappenheimer bodies are made of:

non-heme iron

What stain is used to verify siderocytes?

Prussian blue

Basophilic stippling is characteristic of what iron metabolism disorder?

lead poisoning

What iron metabolism deficiency has these results:

serum iron: variable

ferritin: normal

TIBC: normal

lead poisoning

A hereditary or acquired condition that causes iron excess is called:

hemochromatosis

Which anemia has red cell morphology similar to that seen in iron deficiency anemia:

• Sickle cell anemia

• Thalassemia syndrome

• Pernicious anemia

• Hereditary spherocytosis

Thalassemia syndrome

Which of the following parameters may be similar for the anemia of inflammation and iron deficiency anemia:

• Normocytic indices

• Decreased serum iron

• Ringed sideroblasts

• Pappenheimer bodies

Decreased serum iron

What is the basic hematologic defect seen in patients with thalassemia major:

• DNA synthetic defect

• Hgb structure

• Beta chain synthesis

• Hgb phosphorylation

Beta chain synthesis

The osmotic fragility test result in a patient with thalassemia major would most likely be:

• Increased

• Decreased

• Normal

• Decreased after incubation at 37 degrees C.

Decreased

Skeletal abnormalities and marrow hypertrophy are present in thalassemia major patients due to:

• Depletion of calcium

• Unbalanced globin chain production

• Erythropoietin deficiency

• Hypersplenism

Unbalanced globin chain production

Which of the following is the primary Hgb in patients with thalassemia major:

• Hgb D

• Hgb A

• Hgb C

• Hgb F

Hgb F