IPS1-A6- Liquid Crystalline and Supercritical Fluids

Proverbs 16:3

Mesophase

_____-

• Aka Liquid crystalline

• Intermediate phase between solid and liquids

Mesophase

____- is the 4th phase of matter in Physical Pharmacy

1. Rigid

2. Organic

3. Possesses strong dipole and easily polarizable group

4. Elongated and rectilinear in shape

4 Characteristics of molecules that form mesophases

Mnemonic : ROPE

Liquid crystalline

[Liquid crystalline / Solid crystalline] _____ - is considered as a mesophase

Liquid Crystalline

____ crystalline has flow properties, birefringent, exhibit color changes with temperature, sensitive to electric fields, anisotropic

• Thermotropic Liquid Crystalline (LC)

• Lyotropic Liquid Crystalline (LC)

Types of Liquid Crystalline [2]

Thermotropic LC

[Types of Liquid Crystalline]

____-

• Result from heating of solids

• Smectic

• Nematic

• Cholesteric

Types of Thermotropic Liquid Crystalline [3]

Smectic

[Identify the Type of Thermotropic Liquid Crystalline]

_____-

• layer-like arrangement

• Soap/grease like

• most pharmaceutically important

Nematic

[Identify the Type of Thermotropic Liquid Crystalline]

____-

• Thread-like

• most sensitive to electric field

Nematic

[Identify the Type of Thermotropic Liquid Crystalline]

___-

• parallel arrangement

• used in LCDs

Cholesteric

[Identify the Type of Thermotropic Liquid Crystalline]

____-

• Chiral nematic

• special type of nematic found free in nature

Cholesteric

[Identify the Type of Thermotropic Liquid Crystalline]

____-

• atherosclerosis

• cork-screw arrangement

Cholesteric

[Identify the Type of Thermotropic Liquid Crystalline]

____-

• structure for cholesterol

• involve in atherosclerosis

Lyotropic LC

[Types of Liquid Crystalline]

____-

• Results from action of certain solvents on solids

• Lamellar

• Hexagonal

• Cubic

• Lyotropic Nematic

Type of Lyotropic Liquid Crystalline [4]

Mnemonic: LaHeCuLy

a.) Lamellar

Type of Lyotropic Liquid Crystalline that is:

• most important pharmaceutically

• used in liposomal DDS

a.) Lamellar

b.) Hexagonal

c.) Cubic

d.) Lyotropic Nematic

False;

• Supercritical Fluid is not a mesophase

[T/F] Supercritical Fluid is a mesophase

Supercritical Fluid

[Kind of Fluid]

___ -

• Exhibit properties intermediate between liquid and gas

• Exists under high Temperature and Pressure beyond critical point

• CO₂ and water used in decaffeination of coffee

• Chromatography of polar drugs

• Elimination of toxic waste

Supercritical Fluid Applications [3]

CO₂ and Water

____ [2] are used in the decaffeination of coffee

0.008%

Residual caffeine content in decaffeinated coffee = ____ %

d.) all of these

Supercritical Fluid can be applied in:

a.) CO2 and water used in decaffeination of coffee

b.) Chromatography of polar drug

c.) Elimination of toxic waste

d.) all of these