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__ are those functions of a living organism that display a rhythm of about 24 hours
Circadian rhythms
__ maybe behavioral, physiological, or biochemical
Rhythms
__ means active during the light
__ means active during the dark
Diurnal
Nocturnal
Circadian rhythms are generated by an __ clock
endogenous clock
A __ animal is maintaining its own cycle without external cues
free-running animal
The __, or time between two similar points of successive cycles, may not be exactly 24 hours
period
A __ is the shift in activity in response to a synchronizing stimulus, such as light or food
phase shift
The biological clock is in the __ located above the optic chiasm in the hypothalamus
suprachiasmatic nucleus (SCN)
Transplant studies proved that the __ period is generated in the SCN
endogenous period
__ rhythms occur less than once per day and last longer than a day
Infradian rhythms
Some rhythms are driven by __ factors, such as food availability and temperature
Exogenous factors
An endogenous circannual clock, separate from the SCN, runs at approximately __ days
365 days
__ rhythms occur more than once per day and are shorter than a day; can last for minutes to hours
Ultradian rhythms
__ is synchronized to external events, including light and dark
Sleep
Stimuli like lights, food, jobs, and alarm clocks entrain us to be __ or to __
awake or to sleep
In the absence of cues, humans have a free-running period of approximately __ hours
25 hours
Electrical __ potentials can be used to classify levels of arousal and states of sleep
Electrical brain potentials
__ records electrical activity in the brain
Electroencephalography (EEG)
__ records eye movements
Electro-oculography (EOG)
__ records muscle activity
Electromyography (EMG)
What are the 2 distinct classes of sleep?
Non-REM sleep (NREM)
Rapid-eye movement sleep (REM)
__ can be divided into 3 stages and is characterized by lack of rapid eye movements
Non-REM sleep (NREM)
__ is characterized by small-amplitude, fast EEG waves, no postural tension, and rapid eye movements
Rapid-eye-movement sleep (REM)
An awake person's activity is dominated by a mix of high __ and low __ waves. This is known as beta activity or desynchronized EEG
high frequency; low amplitude
__ rhythm appears during relaxation, regular oscillation at 8 to 12 Hz
Alpha rhythm
__ sleep begins when vertex spikes appear. Heart rate slows, muscle tension decreases, eyes roll, and it lasts several minutes
Stage 1 sleep
__ sleep is defined by waves of 12-14 Hz that occur in bursts (sleep spindles). K-complexes appear (sharp negative EEG potentials)
Stage 2 sleep
__ sleep is defined by the appearance of large-amplitude, very slow waves called delta waves. By this time, delta waves are dominant.
Stage 3 sleep or Slow-wave sleep (SWS)
Night terrors and sleep walking happen in which stage of sleep?
Stage 3 or SWS
__ sleep follows active EEG with small-amplitude, high frequency waves, like an awake person. Muscles are relaxed; flaccid and unresponsive
REM sleep (paradoxical sleep)
A typical young adult sleeps __ hours; 45-50% is stage 2 sleep, and 20% is REM sleep
7-8 hours
Cycles early in the night have more __ sleep, and later cycles have more __ sleep
Stage 3 or SWS; REM sleep
At puberty, most people shift their circadian rhythm of sleep so that they get up __ in the day
later
Vivid dreams occur during __ sleep, and are characterized by visual imagery and a sense that the dreamer is there
REM sleep
__ are long frightening dreams that awaken the sleeper from REM sleep
Nightmares
__ are sudden arousals from NREM sleep, marked by fear and autonomic activity
Night terrors
Infant sleep is characterized by __ sleep cycles and more __ sleep
shorter; REM sleep
As people age, total time asleep __, and the number of awakenings __.
declines; increases
The most dramatic decline is the loss of time spent in stage __
Stage 3
__ is the partial or total prevention of sleep
Sleep deprivation
Effects of sleep deprivation are
Increased __
Difficulty in __
Episodes of __
Increased irritability
Difficulty in concentrating
Episodes of disorientation
Total sleep deprivation compromises the __ system and leads to death
immune system
__ is the process of sleeping more than normal after a period of deprivation
Sleep recovery
On night 1, Stage __ sleep is increased, usually at the expense of Stage __ sleep
Stage 3 sleep
Stage 2 sleep
On night 2, most recovery of __ sleep, which is more intense than normal with more rapid eye movements
REM sleep
One role of sleep is to conserve __
energy
Among plant-eaters, small animals sleep __ than large ones; in correlation with their high metabolic rate
more than
In predatory species, there is no such correlation. Small animals tend to sleep much __ than prey species
much more than
Sleep restores the __ by replenishing metabolic requirements, such as proteins
body
Most __ are released during SWS
growth hormones
__ improves declarative memory
Sleep
__ increases the likelihood of creating false memories
Sleep deprivation
__ may help consolidate nondeclarative memory
REM sleep
Evidence suggests that patterns of neuronal activity seen while a task is being learned during wakefulness are rehearsed during __ sleep
NREM sleep
People who hardly sleep at all may be more efficient sleepers because they demonstrate less Stage __ and __ sleep than the average person
Stage 1 and 2 sleep
Sleep is an active state mediated by
A __ system that displays SWS
A __ system that activates the forebrain into wakefulness
A pontine system that triggers __ sleep
A __ system that affects the other three
A forebrain system
A brainstem system
REM sleep
A hypothalamic system
__, that cause unconsciousness, produce slow waves in EEG that resemble SWS
General anesthetics
Almost all general anesthetics are agonists of __ receptors, which suggests some brain system uses this to promote SWS.
GABA(A) receptors
__ is made by an incision between the medulla and the spinal cord
Isolated brain
Animals showed signs of sleep and __, proving that the networks reside in the brain
wakefulness
__ is made by an incision in the midbrain
Isolated forebrain
The electrical activity in the forebrain showed constant __ but not __. Thus, the forebrain alone can generate this
SWS but not REM
The constant SWS activity in the forebrain is generated by the __ forebrain
basal forebrain
Neurons in the basal forebrain become active at sleep onset and release __
GABA
The __ formation is able to activate the cortex
reticular formation
Electrical stimulation in the cortex will wake up sleeping animals, while lesions of the cortex produce __ sleep
persistent sleep
The forebrain and reticular formation guide the brain between __ and __
SWS and wakefulness
Large lesions of the __ abolish REM sleep
pons
Neurons of the __ are only active during REM sleep
subcoeruleus
Neurons of the subcoeruleus inhibit __ neurons to keep them from firing during REM sleep
motor neurons
Lesions of the subcoeruleus prevent the loss of __ during REM sleep
muscle tone
The study of __ revealed a hypothalamic sleep center
narcolepsy
Narcolepsy sufferers enter __ immediately after falling asleep
REM sleep
Narcolepsy sufferers may show __, a sudden loss of muscle tone, leading to collapse
cataplexy
Destroying neurons that possess __ receptors causes narcolepsy
hypocretin
Hypocretin secreting neurons in the __ project to other sleep system centers: the basal forebrain, reticular formation, and the subcoeruleus
hypothalamus
The hypothalamic hypocretin neurons normally control the transition between __ and __
NREM and REM
__ is the brief inability to move just before falling asleep or just after waking up
Sleep paralysis
Sleep paralysis maybe caused by the __ center continuing to signal for muscle relaxation even when awake
pontine center
__ occurs during stage 3 SWS and may persist into adulthood. Most are not acting out a dream
Somnambulism (sleepwalking)
__ is characterized by organized behavior from an asleep person
REM behavior disorder (RBD)
RBD usually begins after age 50 and is followed by beginning symptoms of __ disease and dementia, which suggests this is the start of a widespread neurodegeneration
Parkinson's disease
__ is a difficulty in falling asleep and can be caused by situational factors, such as shift work or jet lag. Very common
Sleep-onset insomnia
__ is a difficulty in staying asleep and may be caused by drugs or neurological factors
Sleep-maintenance insomnia
In __, breathing may stop or slow down; blood oxygen drops rapidly. Maybe accompanied by snoring
sleep apnea
Sleep apnea arises either from progressive __ of muscles of the chest, diaphragm, and throat cavity or from changes in the pacemaker respiratory neurons of the brainstem
relaxation
A __ machine is a treatment used to prevent the collapse of the airways
CPAP (continuous positive airway pressure)
Untreated sleep apnea can lead to __ disorders
cardiovascular disorders
Does everyone with sleep apnea snore?
No
__ is sleep apnea resulting from immature respiratory pacemaker systems or arousal mechanisms
Sudden infant death syndrome (SIDS)
Putting babies to sleep on their __ can prevent suffocation due to apnea
backs
Most sleeping pills bind to __ receptors throughout the brain
GABA receptors
Continued use of sleeping pills
Makes them __
Produces marked changes in sleep patterns
Can lead to __ and memory gaps
Makes them ineffective
Can lead to drowsiness and memory gaps
Eating behaviors happen multiple times throughout the day. This is an example of a(n):
Circadian rhythm
Circannual rhythm
Infradian rhythm
Ultradian rhythm
Ultradian rhythm
Night terrors and sleepwalking occur during which stage of sleep?
REM
NREM 1
NREM 2
NREM 3
NREM 3
__ is a disorder that involves the loss of smooth transitions between sleep stages
Narcolepsy
Narcolepsy has revealed that the __ uses neurotransmitter hypocretin to control transitions between waking, NREM sleep, and REM sleep
hypothalamus
The basal forebrain is especially involved in __ and __ sleep
NREM & SWS sleep
During REM sleep the motor neurons of a healthy individual should be __/__
inhibited/paralyzed
An individual is asleep, and the EEG is showing large numbers of delta waves. This person seems to be in the __ stage of sleep
NREM 3 stage