Cytokines and Chemokines Lecture Notes

Flashcards about Cytokines and Chemokines

Cytokines

Soluble factors produced by both innate and non-immune cells that facilitate communication within the immune system.

Chemokines

A subset of cytokines that play a major role in cell migration.

Lymph Node Structure

Environment designed to maximize the chance of interactions between real antigen-specific T cells and antigen-presenting cells.

Immunological Synapse

A classic mechanism involving cell contact dependent mechanism for cell communications.

Cytokine definition

Low molecular weight proteins produced by cells that act on other cells through cell surface receptors, delivering positive or negative signals.

Types of Cytokines

Type of cytokines including interleukins, interferences, TNF, and TMSF.

Lymphokine

Cytokines produced by lymphocytes.

Monokine

Cytokines produced by monocytes or macrophages.

Cytokine Receptor Structure

Extracellular domain for cytokine binding and cytoplasmic tail involved in signaling transduction.

Pleiotropic

A property of cytokines where one cytokine can act on multiple cell types.

Redundant

A property of cytokines where multiple cytokines have the same effect.

Synergistic

A property where cytokines enhance each other's effects.

Antagonistic

A property of cytokines exhibiting opposing effects

Autocrine

Cytokine action where a cytokine acts on the cell that produced it.

Paracrine

Cytokine action where a cytokine acts on neighboring cells.