Measles

Paramyxoviridae

Measles family

Single-stranded, negative-sense RNA genome

Paramyxoviridae genome

cows

measles is likely a zoonosis from

10th century

When was the first recorded case of measles?

3000 BCE

When did measles emerge?

morbilivirus

Measles is a

humans, dogs, cattle, etc

morbillivirus

respiratory

How is measles transmitted?

Fever, Rash, cough, diarrhea

What are the symptoms?

SSPE: Chronic Brain Infection, immunosuppression

What is are severe symptoms?

Enters airway → infects macrophages & dendritic cells → moves to lymph nodes→ sever depletion of memory cells → spreads to lymph tissues & organs → spreads to epithelium in airway → viral particles released via coughing & sneezing

How does measles spread into and out of body

memory T & B cells

measles depletes

‘Immune Amnesia’

Immunosuppression is caused by

opportunistic infections

complications or death during measles can often be because of

years

immunosuppression from measles can last for

pathogens

measles can eliminate the memory and thus immunity of how to protect against other

6 proteins

measles only encodes

Hemagglutinin

What protein on the surface binds to the receptor of the host cell?

Nucleoprotein

What protects the RNA genome?

cognitive decline, impaired motor functions, seizures

Symptoms of SSPE

threshold

measles has a hard immunity

near complete worldwide coverage

eliminating measles would require

Basic Reproduction #

Average # of cases of an infection disease that arise by individual

disease will decline

R < 1

disease will grow

R > 1

airborne transmission

Measles R = 15

R

Herd immunity lowers

infection or vaccination

How is herd immunity achieved?

long-lasting

measles immune memory is