RBC Disorders

Microcytic, hypochromic RBCs, decreased reticulocyte - what condition

Iron Deficiency Anemia

fatigue, pallor, koilonychia, angular stomatitis - what condition

Iron Deficiency Anemia

decreased Hb, MCV, ferritin, increased transferrin

Iron Deficiency Anemia

Microcytic RBCs, target cells, basophilic stippling - what condition

Thalassemia (esp. β)

decreased MCV, normal/high RBC count, increased HbA2 - what condition

Thalassemia (esp. β)

Basophilic stippling, microcytic RBCs, positive urine ALA and coprophyrin - what condition

lead poisoning

Abdominal pain, neuropathy, Burton’s lines on gums, skin rash, pallor - what condition

lead poisoning

Basophilic stippling, ring sideroblasts (in marrow), pappenheimer bodies, microcyte - what condition

sideroblastic anemia

Macrocytes, oval RBCs, hypersegmented neutrophils, increased homocysteine - what condition

megaloblastic anemia (vitamin B12/folate deficiency)

atrophic glossitis, neurologic symptoms - what condition

vitamin B12 deficiency megaloblastic anemia

atrophic glossitis, no neurologic symptoms - what condition

folate deficiency megaloblastic anemia

Spherocytes (no central pallor), small round RBCs, increased RDW and OF - what condition

hereditary spherocytosis

agglutination, microspherocyte, positive DAT - what condition

autoimmune hemolytic anemia (AIHA)

bite cells, ghost cells, heinz bodies, no fluorescence - what condition

G6PD deficiency

Normocytic or macrocytic RBCs, pancytopenia, hypocellular marrow - what condition

aplastic anemia

target cells, acanthocytes - what condition

liver disease

Normocytic RBCs, may have ghost cells during hemolysis, morning cola urine, pancytopenia, flow cytometry CD55&59 - what condition

paroxysmal nocturnal hemoglobinuria (PNH)

stomatocyte, theta cell - what condition

SEA ovalocytosis

hemoglobinemia, hemoglobinuria, hemosiderin - what condition

intravascular hemolysis

burr cell, microcyte - what condition

pyruvate kinase deficiency

raynaud finger pallor - what condition

cold type autoimmune hemolytic anemia

dark red urine, worsen with sun and P450 drugs, alcohol, barbiturates - what condition

porphyria

increased PBG & ALA - what condition

acute intermittent porphyria

increased uroporphyrinogen, photosensitive, hyperpigmentation - what condition

porphyria cutanea tarda

macrocyte - present in what conditions

megaloblastic anemia, myelodysplastic syndrome

microcyte - present in what conditions

iron deficiency, thalassemia, sideroblastic anemia, pyruvate kinase deficiency, inflammation

ovalocyte - present in what conditions

megaloblastic anemia, iron deficiency, myelofibrosis, hereditary elliptocytosis

spherocyte - present in what conditions

hemolytic anemia (especially AIHA), thalassemia, burn, hereditary spherocytosis

dacryocyte (tear drop) - present in what conditions

thalassemia, drug-induced heinz bodies, myelofibrosis

drepanocyte (sickle) - present in what conditions

HbS disease (sickle cell anemia)

keratocyte (horn) - present in what conditions

disseminated intravascular coaguulation (DIC), thalassemia, pyruvate kinase deficiency

schistocyte (fragment) - present in what conditions

hemolytic anemia, disseminated intravascular coagulation (DIC), thrombotic, microangiopathic hemolytic anemia

acanthocyte (spur) - present in what conditions

alcoholic liver cirrhosis, post-splenectomy

echinocyte (burr) - present in what conditions

pyruvate kinase deficiency, liver/kidney failure

codocyte (target) - present in what conditions

iron deficiency, thalassemia (HbE), sickle cell

stomatocyte - present in what conditions

liver disease

dimorphism - present in what conditions

post-blood transfusion, sideroblastic anemia, megaloblastic anemia

rouleaux formation - present in what conditions

plasma cell (multiple) myeloma, waldenstrom’s macroglobulinemia

howell-jolly bodies - present in what conditions

megaloblastic anemia, thalassemia, hemolytic anemia, splenectomy (hereditary spherocytosis, sickle cell anemia)

heinz bodies - present in what conditions

G6PD

basophilic stippling - present in what conditions

lead poisoning, beta thalassemia, megaloblastic anemia

pappenheimer bodies - present in what conditions

thalassemia, sideroblastic anemia, hemolytic anemia, post-splenectomy